4-Cyclopropyl-2-isopropylpyrimidine-5-carboxylic acid | 954232-95-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Cyclopropyl-2-isopropylpyrimidine-5-carboxylic acid
• 英文别名: 4-cyclopropyl-2-propan-2-ylpyrimidine-5-carboxylic acid
• CAS: 954232-95-2
• 化学式: C₁₁H₁₄N₂O₂
• 分子量: 206.244
• InChiKey: URBVXNMUFPVKDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Dpp-IV inhibitors
  申请人：Santhera Pharmaceuticals (Schweiz) AG

  公开号：EP2019099A1

  公开（公告）日：2009-01-28

  The invention relates to compounds of formula (I) wherein R1, R2, R3 and n have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament.

  本发明涉及式（I）化合物，其中R1、R2、R3和n的含义如描述和权利要求中所述。所述化合物可用作DPP-IV抑制剂。本发明还涉及制备这种化合物以及将其作为药物的生产和使用。
• [EN] DPP-IV INHIBITORS<br/>[FR] INHIBITEURS DE DPP-IV
  申请人：SANTHERA PHARMACEUTICALS CH

  公开号：WO2009003681A1

  公开（公告）日：2009-01-08

  The invention relates to compounds of formula (I) wherein R1, R2, R3 and n have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament.