4-(5-methylfuran-2-yl)-2,6-diphenylpyridine | 122009-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(5-methylfuran-2-yl)-2,6-diphenylpyridine
• CAS: 122009-49-8
• 化学式: C₂₂H₁₇NO
• 分子量: 311.383
• InChiKey: UYCZHCKFWTYURH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(5-Methylfuran-2-yl)-1,5-diphenylpentane-1,5-dione 在 高氯酸 、 氨 作用下， 以 乙酸酐 为溶剂， 生成 4-(5-methylfuran-2-yl)-2,6-diphenylpyridine
  参考文献：
  名称：

  呋喃基取代的吡啶以及吡啶鎓和吡啶鎓盐的合成及光谱性质

  摘要：

  DOI：

  10.1007/bf00475680

文献信息

• Mesoporous nanocrystalline MgAl2O4: A new heterogeneous catalyst for the synthesis of 2,4,6-triarylpyridines under solvent-free conditions
  作者：Javad Safari、Zohre Zarnegar、Mahmoud Borujeni

  DOI：10.2478/s11696-013-0361-5

  日期：2013.1.1

  In this paper, one-pot synthesis of 2,4,6-triarylpyridine by condensation of subsisted acetophenone (II), aromatic aldehydes (I), and ammonium acetate (III) in the presence of nanocrystalline MgAl2O4 as a new heterogeneous catalyst under solvent-free conditions is reported. Advantages of this method are the use of spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chlorobenzaldehydes, a new nanocatalyst with high surface area, shorter reaction time, easier workup, higher yield, and its environmental friendliness. The performance of this reaction under solvent free conditions using heterogeneous catalysts like MgAl2O4 could enhance its efficiency from an economic as well as green chemistry point of view.

  本文报道了在无溶剂条件下利用纳米晶MgAl2O4作为新型非均相催化剂，通过对存在的苯乙酮（II）、芳香醛（I）和醋酸铵（III）进行缩合反应，合成2,4,6-三芳基吡啶的一锅法合成方法。该方法的优点包括使用空间受阻的醛类化合物，如2-甲氧基、2-氟和2-氯苯甲醛，采用具有高比表面积的新型纳米催化剂，反应时间短，操作简便，产率高，且环保友好。在无溶剂条件下利用MgAl2O4等非均相催化剂进行此反应，能够从经济和绿色化学的角度提高其效率。
• Ultrasound-Mediated Synthesis of 2,4,6-Triaryl-Pyridines Using MgAl2O4 Nanostructures
  作者：Z. Zarnegar、J. Safari、M. Borjian-borujeni

  DOI：10.1007/s10593-015-1638-0

  日期：2015.3

  Nanocrystalline MgAl2O4 was found to be a highly efficient catalyst for the preparation of 2,4,6-triaryl-pyridines from the reaction of acetophenone derivatives, aryl aldehydes, and ammonium acetate under sonic condition for the first time. The present methodology offers several advantages, such as excellent yields, simple procedure, shorter reaction times, and milder conditions; the catalyst also exhibited remarkable reusable activity. This procedure is much simpler and faster than the protocols published to date.
• NOVIKOV, V. N.;TYMYANSKIJ, YA. R.;FEJGELMAN, V. M.;KNYAZHANSKIJ, M. I., XIMIYA GETEROTSIKL. SOED.,(1988) N 10, S. 1320-1324
  作者：NOVIKOV, V. N.、TYMYANSKIJ, YA. R.、FEJGELMAN, V. M.、KNYAZHANSKIJ, M. I.

  DOI：——

  日期：——