(2-chlorobenzyl)(4,5-dihydro-1H-imidazol-2-yl)amine hydroiodide | 6181-68-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-chlorobenzyl)(4,5-dihydro-1H-imidazol-2-yl)amine hydroiodide
• 英文别名: N-[(2-chlorophenyl)methyl]-4,5-dihydro-1H-imidazol-2-amine;hydroiodide
• CAS: 6181-68-6
• 化学式: C₁₀H₁₂ClN₃*HI
• 分子量: 337.591
• InChiKey: SNAWGFZRZRKURR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  36.4
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲硫基-2-咪唑啉 、 邻氯苯甲胺 反应 0.08h， 以95%的产率得到(2-chlorobenzyl)(4,5-dihydro-1H-imidazol-2-yl)amine hydroiodide
  参考文献：
  名称：

  Microwave-Induced Synthesis of 2-Aminoimidazolines Under Neat Conditions

  摘要：

  2-Aminoimidazolines were synthesized by the nucleophilic substitution reaction of 2-methylmercapto-4,5-dihydroimidazole hydroiodide with various amine compounds under neat conditions.

  DOI：

  10.1080/00397910902739896

文献信息

• 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, Salts Thereof and Methods of Using the Same in Combination Therapy
  申请人：ONCOCEUTICS, INC.

  公开号：US20140335048A1

  公开（公告）日：2014-11-13

  This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.

  本披露至少涉及一种治疗方法。在一种实施例中，该治疗方法包括向需要该治疗的受试者施用第一治疗剂，包括化合物（1）或其药学上可接受的盐，与第二治疗剂的组合，其中第一治疗剂和第二治疗剂同时或依次给予。
• 7-BENZYL-4-(METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO[1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5 (1H)-ONE, SALTS THEREOF AND METHODS OF USING THE SAME IN COMBINATION THERAPY
  申请人：Oncoceutics, Inc.

  公开号：US20180360838A1

  公开（公告）日：2018-12-20

  This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
• US9376437B2
  申请人：——

  公开号：US9376437B2

  公开（公告）日：2016-06-28
• Microwave-Induced Synthesis of 2-Aminoimidazolines Under Neat Conditions
  作者：Murat Genc、Süleyman Servi

  DOI：10.1080/00397910902739896

  日期：2009.8.20

  2-Aminoimidazolines were synthesized by the nucleophilic substitution reaction of 2-methylmercapto-4,5-dihydroimidazole hydroiodide with various amine compounds under neat conditions.