perfluoro-N-cyclohexylpyrrolidine | 86714-21-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: perfluoro-N-cyclohexylpyrrolidine
• 英文别名: N-(F-cyclohexyl)-F-pyrrolidine；2,2,3,3,4,4,5,5-octafluoro-1-(1,2,2,3,3,4,4,5,5,6,6-undecafluorocyclohexyl)pyrrolidine
• CAS: 86714-21-8
• 化学式: C₁₀F₁₉N
• 分子量: 495.086
• InChiKey: ZYYBBMCBAFICKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  perfluoro-N-cyclohexylpyrrolidine 在 五氟化锑 作用下， 反应 12.0h， 以42%的产率得到2,2,3,3,4,4,4-Heptafluoro-N-(1,2,2,3,3,4,4,5,5,6,6-undecafluoro-cyclohexyl)-butyrimidoyl fluoride
  参考文献：
  名称：

  Isomerization of perfluorinated cyclic amines under the action of antimony pentafluoride

  摘要：

  DOI：

  10.1007/bf00958050
• 作为产物：
  描述：

  1-环己基吡咯烷 以56%的产率得到
  参考文献：
  名称：

  ONO, TAIZO;INOUE, YOSHIHISA;ARAKAWA, YOSHIO;NAITO, YOUICHIRO;FUKAYA, CHIK+, J. FLUOR. CHEM., 43,(1989) N, C. 67-85

  摘要：

  DOI：

文献信息

• NANOEMULSIONS AND USE THEREOF AS CONTRAST AGENTS
  申请人：GUERBET

  公开号：US20140234223A1

  公开（公告）日：2014-08-21

  The invention relates to an oil-in-water nanoemulsion for MRI, including: an aqueous phase, a fluorinated phase including at least one fluorinated oil, a surfactant at the interface between the aqueous and fluorinated phases, the surfactant comprising: at least one amphiphilic targeting ligand, at least one amphiphilic lipid, and at least one diblock or triblock fluorophilic compound, as well as to the use thereof as a contrast agent.

  这项发明涉及一种用于磁共振成像的油包水纳米乳液，包括： 水相， 含有至少一种氟化油的氟化相， 位于水相和氟化相之间的表面活性剂，所述表面活性剂包括： 至少一种两性靶向配体， 至少一种两性脂质，以及 至少一种二嵌段或三嵌段亲氟化合物， 以及将其用作对比剂的用途。
• Synthesis of perfluorochemicals for use as blood substitutes. Part IV. Electrochemical fluorination of N-cycloalkyl-pyrrolidines and -piperidines
  作者：Taizo Ono、Yoshihisa Inoue、Yoshio Arakawa、Youichiro Naito、Chikara Fukaya、Kouichi Yamanouchi、Kazumasa Yokoyama

  DOI：10.1016/s0022-1139(00)81637-1

  日期：1989.4

  Electrochemical fluorination of N-cyclopentylpyrrolidine gave the corresponding F-amine together with a ring-opened compound N-(F-pentyI)-F-pyrrolidine in the ratio of 1 to 1, in 55% yield. N-cyclohexylpyrrolidine, N-cyclopentylpiperidine, and N-cyclohexylpiperidine were also eletrochemically fluorinated in the same manner to give the corresponding F-amines, their isomers with rearranged structures

  N-环戊基吡咯烷的电化学氟化以1∶1的比例得到相应的F-胺和开环的化合物N-（F-pentyI）-F-吡咯烷，产率为55％。N-环己基吡咯烷，N-环戊基哌啶和N-环己基哌啶也以相同的方式进行电子氟化，得到相应的F-胺，其重排结构的异构体和开环的胺，比率为-4：2：1 ，和2：1：1分别以51％至53％的收率。提供了支持的光谱数据。
• Perfluorocarbon emulsions and their preparation and use in therapy
  申请人：ADAMANTECH, INC.

  公开号：EP0105584A1

  公开（公告）日：1984-04-18

  Perfluorocarbon emulsions may be used to enhance the activity of lipophilic drugs, chemotherapy and chemical and radiation therapy of cancer. Preferred methods for preparing the emulsion and compositions comprising the emulsion are described.

  全氟碳化合物乳剂可用于提高亲脂性药物、化疗以及癌症化学和放射治疗的活性。本文介绍了制备乳剂和包含乳剂的组合物的优选方法。
• Perfluoro carbon compound aqueous dispersions
  申请人：AFFINITY BIOTECH, INC.

  公开号：EP0158996A2

  公开（公告）日：1985-10-23

  Compositions having enhanced gas and drug transporting capability, are prepared by providing a perfluoro compound dispersed in an aqueous medium with a surfactant to form an aqueous initial dispersion, concentrating the perfluoro compound phase of the dispersion as by centrifugation or filtration, wherein a portion of the surfactant remains complexed with the particles of the perfluoro compound phase and the balance of the surfactant is in the aqueous phase, separating the phases, and redispersing the particles of the concentrated perfluoro compound phase to form a final dispersion in which a major portion of the surfactant is complexed with the perfluoro compound particles.

  具有增强气体和药物运输能力的组合物的制备方法是：将全氟化合物与表面活性剂一起分散在水介质中，形成水性初始分散液，通过离心或过滤浓缩分散液中的全氟化合物相、分离两相，并重新分散浓缩后的全氟化合物相的颗粒，形成最终分散液，其中大部分表面活性剂与全氟化合物颗粒复合。
• Novel compositions useful for delivering compounds into a cell
  申请人：ImaRx Pharmaceutical Corp.

  公开号：EP1046394A2

  公开（公告）日：2000-10-25

  The present invention is directed, inter alia, to compositions and their use for delivering compounds into a cell. In a preferred embodiment, the compositions comprise, in combination with the compound to be delivered, an organic halide, a targeting ligand, and a nuclear localization sequence, optionally in the presence of a carrier. Ultrasound may be applied, if desired. The compositions are particularly suitable for the treatment of inflammatory diseases.

  本发明主要涉及将化合物递送到细胞中的组合物及其用途。在一个优选的实施方案中，组合物与待递送的化合物结合在一起，包括有机卤化物、靶向配体和核定位序列，可选择存在载体。如果需要，还可以使用超声波。这些组合物尤其适用于治疗炎症性疾病。