Zn[3,5-bis(trifluoromethyl)phenyl]2 | 1286261-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Zn[3,5-bis(trifluoromethyl)phenyl]2
• 英文别名: Zn[3,5-bis(trifluoromethyl)phenyl]₂
• CAS: 1286261-86-6
• 化学式: C₁₆H₆F₁₂Zn
• 分子量: 491.594
• InChiKey: ZMBXQHJXFCALOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  Zn[3,5-bis(trifluoromethyl)phenyl]2 、 1,3-dioxoisoindolin-2-yl 1-tosylpiperidine-4-carboxylate 在 cobalt(II) bromide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以33%的产率得到4-(3,5-bis(trifluoromethyl)phenyl)-1-tosylpiperidine
  参考文献：
  名称：

  钴催化氧化还原活性脂肪族酯的脱羧Negishi偶联

  摘要：

  开发了氧化还原活性脂族酯与有机锌试剂的钴催化脱羧Negishi偶联反应。该方法可以在温和的反应条件下进行高效的烷基-芳基，烷基-烯基和烷基-炔基偶联反应，而无需外部配体或添加剂。原位激活方案的成功实施和药物分子（±）-preclamol的轻松合成凸显了该方法的合成潜力。机理研究表明，涉及一种根本机制。

  DOI：

  10.1002/anie.201806799
• 作为产物：
  描述：

  3,5-双三氟甲基溴苯 、 zinc(II) chloride 在 正丁基锂 作用下， 生成 Zn[3,5-bis(trifluoromethyl)phenyl]2
  参考文献：
  名称：

  Homogeneous Model Complexes for Supported Rhenia Metathesis Catalysts

  摘要：

  A series of rhenium trioxo complexes (L-ReO3) was synthesized, characterized, and demonstrated to be active in olefin metathesis. The relationship between perrhenate (ReO4-), perrhenyl (ReO3+), and metathesis-active rhenium complexes (L-ReO3) was elucidated. Their chemical behavior can be tuned through the Lewis acid-base interaction. DFT calculations were performed for the metathesis reaction of L-ReO3 with norbornene, which demonstrates that electron-withdrawing substituents or ligands are beneficial for olefin metathesis activity. Moreover, a rhenium-alkylidene complex was synthesized, which can be activated by B(C6F5)(3) to afford an active metathesis catalyst. This be regarded as a homogeneous model of the hypothetical species present in the heterogeneous catalytic systems. The findings from the present study are consistent with our previous gas-phase studies and constitute the elucidation of the working principles for the metathesis-active rhenium species on the surface.

  DOI：

  10.1021/om300852s

文献信息

• Nickel-Catalyzed Direct Addition of Diorganozinc Reagents to Phthalimides: Selective Formation of Gamma-Hydroxylactams
  作者：Jeffrey Johnson、Joseph Dennis、Catherine Calyore、Jessica Sjoholm、J. Lutz、Joseph Gair

  DOI：10.1055/s-0033-1339890

  日期：——

  The nickel-catalyzed addition of diorganozinc reagents to phthalimides proceeds with excellent selectivity to provide 3-substituted-3-hydroxyisoindolin-1-one products. These 3-hydroxy--lactams are produced cleanly in high yield with numerous examples of imide substitution and a broad range of diorganozinc reagents that are prepared and utilized without purification.
• Efficient access to 3-substituted-γ-hydroxylactams: the uncatalyzed addition of diorganozinc reagents to cyclic imides with heterocyclic substitution
  作者：Kimberly S. DeGlopper、Joseph M. Dennis、Jeffrey B. Johnson

  DOI：10.1016/j.tetlet.2014.01.130

  日期：2014.3

  A range of 3-substituted-gamma-hydroxylactams have been prepared via the uncatalyzed addition of organo-zinc nucleophiles to cyclic imides. This reactivity is primarily limited to imides containing heterocyclic N-substitution, but proceeds efficiently with a variety of diorganozinc reagents, including those prepared and utilized without purification, as well as organozinc halides. It is hypothesized that the presence of a Lewis basic directing group is required for optimum reactivity. (C) 2014 Elsevier Ltd. All rights reserved.