1-(aziridin-1-yl)-2,2,2-tribromoethanol | 3795-95-7

• 分子结构分类: 有机化合物
• 英文名称: 1-(aziridin-1-yl)-2,2,2-tribromoethanol
• CAS: 3795-95-7
• 化学式: C₄H₆Br₃NO
• 分子量: 323.81
• InChiKey: LNORRRXGWWUXIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙烯亚胺 、 三溴乙醛 以 乙醚 为溶剂， 反应 24.0h， 以70%的产率得到1-(aziridin-1-yl)-2,2,2-tribromoethanol
  参考文献：
  名称：

  2-Carbamoylaziridine (Leakadine): diastereoselective transformations and stereoelectronic effect*

  摘要：

  Diastereoselective transformations of Leakadine were discovered: dimerization during melting or heating in CHCl3 with the formation of one diastereomer. The obtained dimer reacts with methyl isocyanate under mild conditions with the formation of an N-methylcarbamoyl derivative - also in the form of one diastereomer. In the diastereoselective reaction of Leakadine with dimethyl formamide dimethyl acetal, 2-dimethylamino-1,3-diazabicyclo[3.1.0]hexan-4-one was obtained. The reaction of Leakadine with perfluoroisobutylene was studied.

  DOI：

  10.1007/s10593-012-1068-1