nicotine salicylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: nicotine salicylate
• 英文别名: 2-carboxyphenolate;3-(1-methylpyrrolidin-2-yl)pyridin-1-ium
• 化学式: 0C₇H₆O₃*C₁₀H₁₄N₂
• 分子量: 231.296
• InChiKey: AIBWPBUAKCMKNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.94
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  73.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  水杨酸 、 (+/-)-尼古丁 生成 nicotine salicylate
  参考文献：
  名称：

  WO2023/62109

  摘要：

  公开号：

文献信息

• [EN] NICOTINE SALT WITH M ETA-SALICYLIC ACID<br/>[FR] SEL DE NICOTINE AVEC DE L'ACIDE MÉTA-SALICYLIQUE
  申请人：ALEXZA PHARMACEUTICALS INC

  公开号：WO2015006652A1

  公开（公告）日：2015-01-15

  The present disclosure relates generally to the field of nicotine delivery. The disclosure teaches a nicotine meta-salicylate. More specifically, the disclosure teaches a condensation nicotine aerosol where nicotine meta-salicylate is vaporized. This disclosure relates to aerosol nicotine delivery devices. The delivery devices can be activated by actuation mechanisms to vaporize thin films comprising a nicotine meta-salicylate. More particularly, this disclosure relates to thin films of nicotine salt with meta salicylic acid for the treatment of nicotine craving and for effecting smoking cessation.

  本公开涉及尼古丁递送领域。本公开教授一种尼古丁间位水杨酸盐。更具体地，本公开教授一种尼古丁间位水杨酸盐被蒸发的凝结尼古丁气溶胶。本公开涉及气溶胶尼古丁递送装置。这些递送装置可以通过启动机制被激活，以蒸发包含尼古丁间位水杨酸盐的薄膜。更具体地，本公开涉及尼古丁盐与间位水杨酸的薄膜，用于治疗尼古丁渴望并实现戒烟效果。
• [EN] NICOTINE SALTS, CO-CRYSTALS, AND SALT CO-CRYSTAL COMPLEXES<br/>[FR] SELS, CO-CRISTAUX, ET COMPLEXES DE CO-CRISTAUX DE SELS DE NICOTINE
  申请人：REYNOLDS TOBACCO CO R

  公开号：WO2015183801A1

  公开（公告）日：2015-12-03

  The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with mucic acid, 3,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid, and crystalline polymorphic forms of nicotine 4-acetamidobenzoate, nicotine gentisate, and nicotine 1-hydroxy-2-naphthoate are described. The invention further provides methods of preparation and characterization of such nicotine salts, co-crystals, and salt co-crystals and polymorphic forms thereof. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.

  该发明提供了某些尼古丁盐、共晶和盐共晶，并提供了某些尼古丁盐的新颖多形态形式。具体来说，描述了与粘酸、3,5-二羟基苯甲酸和2,3-二羟基苯甲酸结合的尼古丁盐，以及尼古丁4-乙酰氨基苯甲酸、尼古丁吉替酸和尼古丁1-羟基-2-萘酸的结晶多形态形式。该发明还提供了制备和表征这些尼古丁盐、共晶和盐共晶以及其多形态形式的方法。此外，还提供了含有尼古丁盐、共晶和/或盐共晶的烟草制品，包括吸烟物品、无烟烟草制品和电子吸烟物品。
• [EN] HYDROXYLATED TRICYCLIC COMPOUNDS<br/>[FR] COMPOSÉS TRICYCLIQUES HYDROXYLÉS
  申请人：NEKTAR THERAPEUTICS

  公开号：WO2012079017A1

  公开（公告）日：2012-06-14

  The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.

  这项发明提供了通过共价连接水溶性寡聚体进行化学修饰的小分子药物。根据本发明的化合物，当通过多种给药途径之一给予时，表现出与未连接水溶性寡聚体的小分子药物不同的特性。
• Fast dissolving films and coatings for controlled release of flavors, active pharmaceutical ingredients, food substances, and nicotine
  申请人：Selmin Francesca

  公开号：US20090253754A1

  公开（公告）日：2009-10-08

  A fast-dissolving film for use as a platform for the delivery of material to the oral cavity, comprising a film forming agent; a plasticizing agent; and a fast-dissolving, water-soluble agent; and methods for producing same.

  一种用于将物质传递到口腔的平台的快速溶解膜，包括成膜剂；增塑剂；以及快速溶解、水溶性剂；以及其制备方法。
• Oligomer-Aryloxy-Substituted Propanamine Conjugates
  申请人：Riggs-Sauthier Jennifer

  公开号：US20110071207A1

  公开（公告）日：2011-03-24

  The invention relates to (among other things) oligomer-aryloxy-substituted propanamine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated aryloxy-substituted propanamine compounds.

  该发明涉及寡聚物-芳氧基取代的丙胺酰共轭物和相关化合物（除其他外）。该发明的共轭物在通过任何一种给药途径给予时，表现出优于未共轭的芳氧基取代的丙胺酰化合物的优点。