4-羟基-3-亚硝基苯甲酰胺 | 162152-90-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-羟基-3-亚硝基苯甲酰胺
• 英文名称: 4-hydroxy-3-nitrosobenzamide
• CAS: 162152-90-1
• 化学式: C₇H₆N₂O₃
• 分子量: 166.136
• InChiKey: GUWUNALKOAAXJC-UHFFFAOYSA-N

物化性质

• 沸点：
  357.0±37.0 °C(Predicted)
• 密度：
  1.51±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-羟基-3-亚硝基苯甲酰胺 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以10 mg的产率得到3-氨基-4-羟基-苯甲酰胺
  参考文献：
  名称：

  4-Hydroxy-3-nitrosobenzamide and its ferrous chelate from Streptomyces murayamaensis

  摘要：

  Two new colored metabolites of Streptomyces murayamaensis have been isolated and characterized as 4-hydroxy-3-nitrosobenzamide and its ferrous chelate. These structures have been confirmed by synthesis via a modified Baudisch reaction. A sample of 3-amino-4-hydroxy[2-H-2]benzoic acid was fed to S. murayamaensis, affording a sample of the 4-hydroxy-3-nitrosobenzamide ferrous chelate deuterated at C-2 (28.5% enrichment, 3.2% incorporation).

  DOI：

  10.1016/0040-4020(95)00071-f
• 作为产物：
  描述：

  4-羟基苯甲酰胺 在 Chelex-100 resin 、 ammonium bicarbonate 、 copper(II) sulfate 、 sodium nitrite 作用下， 生成 4-羟基-3-亚硝基苯甲酰胺
  参考文献：
  名称：

  4-Hydroxy-3-nitrosobenzamide and its ferrous chelate from Streptomyces murayamaensis

  摘要：

  Two new colored metabolites of Streptomyces murayamaensis have been isolated and characterized as 4-hydroxy-3-nitrosobenzamide and its ferrous chelate. These structures have been confirmed by synthesis via a modified Baudisch reaction. A sample of 3-amino-4-hydroxy[2-H-2]benzoic acid was fed to S. murayamaensis, affording a sample of the 4-hydroxy-3-nitrosobenzamide ferrous chelate deuterated at C-2 (28.5% enrichment, 3.2% incorporation).

  DOI：

  10.1016/0040-4020(95)00071-f

文献信息

• 4-Hydroxy-3-nitrosobenzamide and its ferrous chelate from Streptomyces murayamaensis
  作者：Martha C. Cone、Chris R. Melville、John R. Carney、Makarand P. Gore、Steven J. Gould

  DOI：10.1016/0040-4020(95)00071-f

  日期：1995.3

  Two new colored metabolites of Streptomyces murayamaensis have been isolated and characterized as 4-hydroxy-3-nitrosobenzamide and its ferrous chelate. These structures have been confirmed by synthesis via a modified Baudisch reaction. A sample of 3-amino-4-hydroxy[2-H-2]benzoic acid was fed to S. murayamaensis, affording a sample of the 4-hydroxy-3-nitrosobenzamide ferrous chelate deuterated at C-2 (28.5% enrichment, 3.2% incorporation).