5-Amino-4-isopropylaminopyrimidin | 18202-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Amino-4-isopropylaminopyrimidin
• 英文别名: N⁴-isopropyl-pyrimidine-4,5-diamine；4,5-Pyrimidinediamine, N4-(1-methylethyl)-；4-N-propan-2-ylpyrimidine-4,5-diamine
• CAS: 18202-83-0
• 化学式: C₇H₁₂N₄
• 分子量: 152.199
• InChiKey: PWEGFMVXXGYUTH-UHFFFAOYSA-N

物化性质

• 沸点：
  309.8±27.0 °C(Predicted)
• 密度：
  1.161±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
  申请人：Buckman Brad

  公开号：US20110081315A1

  公开（公告）日：2011-04-07

  The embodiments provide compounds of the general Formulae I, Ia, II, III, IV, V, VI-1, VI-2, VII, VIII, IX, X, XI, and XII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

  本实施例提供了一般式I、Ia、II、III、IV、V、VI-1、VI-2、VII、VIII、IX、X、XI和XII的化合物，以及包括药物组合物在内的组合物。本实施例还提供了治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，这些方法通常涉及向需要该化合物或组合物的个体施用有效量的该化合物或组合物。
• CYCLIC PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION
  申请人：Intermune, Inc.

  公开号：EP2483290A1

  公开（公告）日：2012-08-08
• [EN] CYCLIC PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION<br/>[FR] INHIBITEURS PEPTIQUES CYCLIQUES DE LA RÉPLICATION DU VIRUS DE L'HÉPATITE C
  申请人：INTERMUNE INC

  公开号：WO2011038293A1

  公开（公告）日：2011-03-31

  The embodiments provide compounds of the general Formulae I, Ia, II, III, IV, V, VI-1, VI-2, VII, VIII, IX, X, XI, and XII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.