N-phenyl-7H-purin-8-amine | 103588-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N-phenyl-7H-purin-8-amine
• CAS: 103588-31-4
• 化学式: C₁₁H₉N₅
• 分子量: 211.226
• InChiKey: MVQNETOVPQSKEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4,5-二氨基嘧啶 、 苯基二硫代氨基甲酸甲酯 在 potassium carbonate 、 copper(II) oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以80%的产率得到N-phenyl-7H-purin-8-amine
  参考文献：
  名称：

  二硫代氨基甲酸酯和CuO促进了2-（N-取代）-氨基苯并咪唑及其相关杂环的一锅合成

  摘要：

  描述了一种快速有效的一锅法合成2-（N-取代）-氨基苯并咪唑的方法。该反应由二硫代氨基甲酸酯和催化性CuO促进。该程序是通用的，可用于合成许多潜在的候选药物。

  DOI：

  10.1016/j.tetlet.2007.12.022

文献信息

• A Facile Synthesis of 8-Arylamino- and 8-Hetarylaminopurines and their 1- and 3-Deaza Analogs
  作者：J. Garin、E. Melendez、F. L. Merchan、T. Tejero

  DOI：10.1055/s-1985-35505

  日期：——

  A general method for the synthesis of 8-arylamino- and 8-(2-benzothiazolylamino)-purines and their 1- and 3-deaza analogs is reported. The need for the presence of the desulfurizing agent in the preparation of the 8-arylamino derivatives is demonstrated and evidence for an intermediate thiourea is provided.

  报告了一种合成 8-芳基氨基和 8-(2-苯并噻唑氨基)-嘌呤及其 1-和 3-脱氮类似物的一般方法。该方法证明了在制备 8-芳基氨基衍生物时需要脱硫剂的存在，并提供了中间硫脲的证据。
• Purine Derivatives
  申请人：Salas Solana Jorge

  公开号：US20100204187A1

  公开（公告）日：2010-08-12

  Purine derivatives of Formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.

  公式（I）的嘌呤衍生物，其中各取代基的含义如描述中所披露。这些化合物可用作JAK3激酶抑制剂。
• Recombinant DNA which can be introduced into plant cells
  申请人：PLANT GENETIC SYSTEMS N.V.

  公开号：EP0189707A2

  公开（公告）日：1986-08-06

  The invention relates to chimaeric genes which encode a fusion protein consisting of a transit peptide of a chloroplast protein-precursor, linked directly or indirectly to another protein. It also relates to recombinant vectors containing said chimeric genes suitable for the transformation of plant cells, whereby said another protein can be translocated and processed in the chloroplats.

  本发明涉及嵌合基因，该基因编码由叶绿体蛋白前体的转运肽组成的融合蛋白，该转运肽直接或间接地与另一种蛋白相连。本发明还涉及含有上述嵌合基因的重组载体，适用于植物细胞的转化，从而使上述另一种蛋白质在叶绿体中转运和加工。
• Methods for generating doubled haploid plants
  申请人：Northwest Plant Breeding Company

  公开号：US20020104128A1

  公开（公告）日：2002-08-01

  The present invention provides methods for generating doubled haploid and/or haploid plants from microspores. In a presently preferred embodiment of the methods of the present invention, plant material is selected that bears reproductive organs containing microspores at a developmental stage that is amenable to androgenic induction. The microspores are treated by contacting the selected plant material with water and subjecting the selected plant material to temperature stress, and optionally to nutrient stress. Preferably the selected plant material is contacted with an effective amount of a sporophytic development inducer and an effective amount of an auxin and/or a cell spindle inhibiting agent. Optionally, the selected plant material is contacted with an effective amount of a cytokinin and/or an effective amount of a gibberellin. The treated microspores are isolated, preferably by density centrifugation utilizing a solution of 0.3 M mannitol layered over a higher density solution of a sugar, preferably maltose. The isolated, treated microspores are then cultured in a liquid nutrient suspension medium supplemented with at least one plant ovary or with an aliquot of plant ovary conditioned medium, until the microspores develop into embryoids. The embryoids are transferred to a regeneration medium and incubated therein until the embryoids develop into plants. The resulting plants may be haploid or doubled haploid and may also be genetically transformed.

  本发明提供了用小孢子产生加倍单倍体和/或单倍体植物的方法。在本发明方法的一个目前优选的实施方案中，所选植物材料具有含有小孢子的生殖器官，其发育阶段适于雄性诱导。处理小孢子的方法是将所选植物材料与水接触，并使所选植物材料受到温度胁迫和营养胁迫。最好将所选植物材料与有效量的孢子体发育诱导剂和有效量的辅助素和/或细胞纺锤体抑制剂接触。可选地，将所选植物材料与有效量的细胞分裂素和/或有效量的赤霉素接触。将处理过的小孢子分离出来，最好采用密度离心法，将 0.3 M 的甘露醇溶液分层覆盖在较高密度的糖（最好是麦芽糖）溶液上。然后将分离出的经过处理的小孢子放入液体营养悬浮培养基中培养，培养基中至少添加一个植物子房或等量的植物子房条件培养基，直到小孢子发育成胚胎。胚胎被转移到再生培养基中培养，直到胚胎发育成植株。生成的植物可以是单倍体或加倍单倍体，也可以进行基因转化。
• Methods for generating doubled haploid maize plants
  申请人：——

  公开号：US20020151057A1

  公开（公告）日：2002-10-17

  In one aspect, the present invention provides methods for generating doubled haploid and/or haploid maize plants from microspores. The methods of this aspect of the invention include the steps of: (a) selecting maize plant material comprising maize microspores at a developmental stage amenable to androgenic induction; (b) incubating the microspores in incubation medium at a temperature and osmolarity effective to induce androgenesis to obtain temperature-treated microspores; (c) isolating the temperature-treated microspores; (d) cultivating the isolated, temperature-treated microspores in cultivation medium with either at least one live plant ovary and/or ovary-conditioned medium to produce regenerative maize tissue, wherein the cultivation medium has an osmolarity between about 300 mOsm and about 500 mOsm and comprises at least one cytokinin and at least one auxin; and (e) regenerating maize plants from the regenerative maize tissue. The present invention also provides methods for producing regenerative maize tissue from maize microspores.

  在一个方面，本发明提供了从小孢子产生加倍单倍体和/或单倍体玉米植株的方法。本发明这方面的方法包括以下步骤：(a) 挑选玉米植物材料，该材料包括处于适于雄性诱导的发育阶段的玉米小孢子； (b) 在诱导雄性诱导有效的温度和渗透压下将小孢子在培养基中培养，以获得温度处理的小孢子； (c) 分离温度处理的小孢子；(d) 在具有至少一个活植物子房和/或子房调节培养基的培养基中培养分离的、经温度处理的小孢子，以产生再生玉米组织，其中培养基的渗透压在约300 mOsm和约500 mOsm之间，并包含至少一种细胞分裂素和至少一种辅助素；以及 (e) 从再生玉米组织中再生玉米植株。本发明还提供了从玉米小孢子生产再生玉米组织的方法。