p-Methylacetophenonhydrazon | 64252-53-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Methylacetophenonhydrazon
• 英文别名: (1-P-Tolylethylidene)Hydrazine；(E)-1-(4-methylphenyl)ethylidenehydrazine
• CAS: 64252-53-5
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: BAQJPIGWBCMBDQ-DHZHZOJOSA-N

物化性质

• 熔点：
  34 °C(Solv: ligroine (8032-32-4); benzene (71-43-2))
• 沸点：
  166-168 °C(Press: 16 Torr)
• 密度：
  0.99±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  p-Methylacetophenonhydrazon 、 氧化镁 以85%的产率得到
  参考文献：
  名称：

  THORAVAL, J. Y.;NAGAI, W.;YEUNG, LAM KO Y. Y. C.;CARRIE, R., TETRAHEDRON., 46,(1990) N1, C. 3859-3868

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲基苯乙酮 、 肼 生成 p-Methylacetophenonhydrazon
  参考文献：
  名称：

  THORAVAL, J. Y.;NAGAI, W.;YEUNG, LAM KO Y. Y. C.;CARRIE, R., TETRAHEDRON., 46,(1990) N1, C. 3859-3868

  摘要：

  DOI：

文献信息

• Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
  申请人：——

  公开号：US20020128292A1

  公开（公告）日：2002-09-12

  The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: 1 wherein X, Ar 1 , R 2 -R 6 and R 12 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及取代的吲哚-2-羧酸亚苄基肼及其类似物，其由通式I表示： 1 其中X，Ar 1 ，R 2 -R 6 和R 12 的定义如本文中所述。本发明还涉及发现具有I式的化合物是半胱天冬酶的激活剂和凋亡的诱导剂。本发明的化合物可用于诱导在异常细胞不受控制的生长和扩散发生的多种临床状况中的细胞死亡。
• CURABLE COMPOSITION, CURING PRODUCT, AND METHOD FOR USING CURABLE COMPOSITION
  申请人：Lintec Corporation

  公开号：EP3034543A1

  公开（公告）日：2016-06-22

  The present invention is : a curable composition comprising a component (A) and a component (B) in a mass ratio (component (A):component (B)) of 100:0.1 to 100:50; a cured product obtained by curing the curable composition; and a method for using the curable composition as an optical device-securing adhesive or an optical device sealing material. The component (A) is a silane compound polymer that is represented by a formula (a-1)(where in the formula: R1 is a group selected from an alkyl group having 1 to 20 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms, and a substituted or unsubstituted aryl group having 6 to 20 carbon atoms, Z is a hydroxyl group, an alkoxy group having 1 to 10 carbon atoms, or a halogen atom, m is a positive integer, and n and o are independently 0 or a positive integer, provided that a plurality of R1 are either identical or different, and a plurality of Z are either identical or different.), and the component (B) is a silane coupling agent that comprises a sulfur atom-containing functional group in its molecule.         (R1SiO3/2)m(R1SiZO2/2)n(R1SiZ2O1/2)o ···     (a-1)

  本发明是：一种可固化组合物，包括质量比（组分(A):组分(B)）为100:0.1至100:50的组分(A)和组分(B)；通过固化该可固化组合物获得的固化产品；以及将该可固化组合物用作光学设备固定粘合剂或光学设备密封材料的方法。组分（A）是硅烷化合物聚合物，由式（a-1）表示（式中：R1 是选自具有 1 至 20 个碳原子的烷基、具有 3 至 10 个碳原子的环烷基和具有 6 至 20 个碳原子的取代或未取代芳基的基团，Z 是羟基、具有 1 至 10 个碳原子的烷氧基或卤素原子，m 是正整数，n 和 o 独立地为 0 或正整数，条件是多个 R1 相同或不同，多个 Z 相同或不同。)，而组分(B)是一种硅烷偶联剂，其分子中包含一个含硫原子的官能团。 (R1SiO3/2)m(R1SiZO2/2)n(R1SiZ2O1/2)o --- (a-1)
• CURABLE COMPOSITION, CURED PRODUCT, METHOD FOR USING CURABLE COMPOSITION, AND OPTICAL DEVICE
  申请人：Lintec Corporation

  公开号：EP3187547A1

  公开（公告）日：2017-07-05

  The present invention is a curable composition comprising a component (A), a component (B), a component (C), and a component (D), the curable composition comprising the component (A) and the component (B) in a mass ratio (component (A):component (B)) of 100:0.3 to 100:20, the component (A) being a silane compound (co)polymer that is represented by a formula (a-1) or a formula (a-2),         (CHR1X0-D-SiO3/2)m(R2SiO3/2)n(CHR1X0-D-SiZ1O2/2)o(R2SiZ2O2/2)p(CHR1X0-D-SiZ32O1/2)q(R2SiZ42O1/2)r ···     (a-1)         (R3SiO3/2)s(R3SiZ5O2/2)t(R3SiZ52O1/2)u ···     (a-2) the component (B) being fine particles having an average primary particle size of more than 0.04 µm and 8 µm or less, the component (C) being a silane coupling agent that comprises a nitrogen atom in its molecule, and the component (D) being a silane coupling agent that comprises an acid anhydride structure in its molecule, and an optical element-securing composition, and a cured product, and an optical element-securing material, and a method for using the curable composition, and an optical device.

  本发明是一种可固化组合物，包括组分(A)、组分(B)、组分(C)和组分(D)，该可固化组合物包括组分(A)和组分(B)，其质量比(组分(A):组分(B))为100:0.3至100:20、 组分（A）为硅烷化合物（共）聚合物，由式（a-1）或式（a-2）表示、 (CHR1X0-D-SiO3/2)m(R2SiO3/2)n(CHR1X0-D-SiZ1O2/2)o(R2SiZ2O2/2)p(CHR1X0-D-SiZ32O1/2)q(R2SiZ42O1/2)r --- (a-1) (R3SiO3/2)s(R3SiZ5O2/2)t(R3SiZ52O1/2)u --- (a-2) 组分(B)为平均初级粒径大于 0.04 微米但小于或等于 8 微米的细颗粒、 组分（C）为硅烷偶联剂，其分子中包含一个氮原子，以及 组分（D）为硅烷偶联剂，其分子中包含酸酐结构，以及 光学元件固定组合物，以及 固化产品，以及 光学元件固定材料，以及 使用固化组合物的方法，以及 一种光学设备。
• CURABLE COMPOSITION, METHOD FOR PRODUCING CURABLE COMPOSITION, CURED OBJECT, METHOD FOR USING CURABLE COMPOSITION, AND OPTICAL DEVICE
  申请人：Lintec Corporation

  公开号：EP3187545A1

  公开（公告）日：2017-07-05

  The present invention is : a curable composition comprising a component (A), a component (B), and a component (C), the curable composition comprising the component (A) and the component (B) in a mass ratio (component (A):component (B)) of 100:0.3 to 100:50, the component (A) being a curable polysilsesquioxane compound that comprises a repeating unit represented by a formula (a-1),         R 1 S i O 3/2     (a-1) wherein R1 is a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, or a substituted or unsubstituted aryl group, the component (B) being fine particles having an average primary particle size of 5 to 40 nm, and the component (C) being a silane coupling agent that comprises a nitrogen atom in its molecule. This invention provides: a curable composition that produces a cured product that exhibits excellent adhesion, excellent delamination resistance, and excellent heat resistance, and exhibits excellent workability during the application step, a method for producing the same, a cured product obtained by curing the curable composition, a method for using the curable composition as an optical element-securing adhesive or an optical element sealing material, and an optical device.

  本发明是：一种由组分（A）、组分（B）和组分（C）组成的可固化组合物，该可固化组合物由组分（A）和组分（B）组成，其质量比（组分（A）:组分（B））为 100:0.3 至 100:50，组分（A）是一种可固化聚硅氧烷化合物，它包括由式（a-1）表示的重复单元、 R 1 S i O 3/2 (a-1) 其中 R1 是具有 1 至 10 个碳原子的取代或未取代的烷基，或取代或未取代的芳基；组分（B）是平均主粒径为 5 至 40 纳米的细颗粒；组分（C）是分子中含有一个氮原子的硅烷偶联剂。本发明提供了：一种可固化组合物，该组合物产生的固化物具有优异的粘附性、优异的抗分层性和优异的耐热性，并且在应用步骤中具有优异的可加工性；一种生产该组合物的方法；一种通过固化该可固化组合物得到的固化物；一种将该可固化组合物用作光学元件固定粘合剂或光学元件密封材料的方法；以及一种光学设备。
• Combination of antioxidant substances for the treatment of alzheimer's disease
  申请人：Colba R & D Inc.

  公开号：US20030158237A1

  公开（公告）日：2003-08-21

  Disclosed is a pharmaceutical composition for the treatment of cognitive symptoms caused by Alzheimer's disease in a mammal. This composition comprising vitamin E, quercitin, caffeic acid, nicotinic acid or derivatives and/or analog thereof, and a pharmaceutically acceptable excipient.

  本发明公开了一种药物组合物，用于治疗由阿尔茨海默病引起的哺乳动物认知症状。该组合物包含维生素 E、槲皮素、咖啡酸、烟酸或其衍生物和/或类似物，以及药学上可接受的赋形剂。