4-羟基-3-苯基-2-丁酮 | 62559-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-羟基-3-苯基-2-丁酮
• 英文名称: 1-Hydroxy-2-phenylbutan-3-one
• 英文别名: 4-Hydroxy-3-phenyl-2-butanon；4-Hydroxy-3-phenylbutan-2-one
• CAS: 62559-37-9
• 化学式: C₁₀H₁₂O₂
• 分子量: 164.204
• InChiKey: LXZMKGWDPDBHSO-UHFFFAOYSA-N

物化性质

• 沸点：
  130-135 °C(Press: 0.2 Torr)
• 密度：
  1.090±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2914400090

反应信息

• 作为反应物：
  描述：

  4-羟基-3-苯基-2-丁酮 在 三氟化硼乙醚 、 四氯化钛 、 N-亚硫酰基-p-甲苯磺胺 、 锌 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 17.0h， 生成 4-Methylidene-5-phenyloxathiane 2,2-dioxide
  参考文献：
  名称：

  Convenient Syntheses of Chiral Cyclic Sulfinates (Sultines) from Unsaturated Alcohols

  摘要：

  The reaction of unsaturated alcohols with N-sulfinyl-p-toluenesulfonamide (TsNSO) is shown to lead stereoselectively to chiral cyclic or bicyclic sulfinates (sultines). The reactions occur at ambient temperatures and afford a general route to delta- and epsilon-sultines which are notable for their crystallinity and thermal stability. These studies confirm the preservation of stereochemical integrity of the carbon atom alpha to the oxygen atom in the sultine ring. Some unsaturated aldehydes furnish sultines via a tandem oxo-ene cyclization and subsequent ring closure to the sultine. In some reactions, N-toluenesulfonamide derivatives of sultines (compounds of type 11) were isolated, and since those were converted into the sultines by the action of BF3-OEt(2), such sulfonamides are considered to be intermediates in the reaction pathway.

  DOI：

  10.1021/jo00129a056
• 作为产物：
  描述：

  syn-/anti-1,2-Epoxy-3-phenylbutan-3-ol 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以40%的产率得到4-羟基-3-苯基-2-丁酮
  参考文献：
  名称：

  Stereoselective construction of quaternary centers at ambient temperature by the highly stereocontrolled migration of groups containing sp-, sp2-, and sp3-hybridized carbon atoms

  摘要：

  A very highly diastereoselective semipinacol rearrangement of 2,3-epoxy alcohols mediated by tin(IV) chloride at ambient temperatures is shown to be applicable to a wide variety of migrating groups including methyl, tert-butyl, cyclopropyl, vinyl, alkynyl, phenyl, and 2-furyl. A synthetically valuable feature is that a mixture of syn- and anti-epoxy alcohols affords only a single diastereoisomerically pure beta-hydroxy ketone. Additional advantages of the reaction include the presence in the product of two adjacent stereocenters and the efficient creation of a new quaternary center, valuable features in the synthesis of a variety of natural products.

  DOI：

  10.1021/jo00074a019

文献信息

• [EN] A SOLVENT DRYING COMPOSITION AND PROCESSES THERFOR<br/>[FR] COMPOSITION DE SÉCHAGE PAR SOLVANT ET PROCESSUS ASSOCIÉS
  申请人：AQUAFORTUS TECH LIMITED

  公开号：WO2020204733A1

  公开（公告）日：2020-10-08

  The present disclosure relates to a solvent drying composition and processes therefor. The present disclosure more specifically relates to a solvent drying composition that in use releases water from a solvent mixture. The present disclosure also relates to a process for recovering a solvent drying composition, more specifically to a process for recovering a solvent drying composition used in an osmotic process.

  本公开涉及溶剂干燥组合物及其处理过程。具体而言，本公开涉及一种在使用中从溶剂混合物中释放水的溶剂干燥组合物。本公开还涉及一种用于回收溶剂干燥组合物的过程，更具体地说是用于回收在渗透过程中使用的溶剂干燥组合物的过程。
• [EN] MULTIFUNCTIONAL ALLYL CARBAMATES AND COATINGS THEREFROM<br/>[FR] CARBAMATES D'ALLYLE POLYVALENTS ET ENDUITS PRODUITS AU MOYEN DE CEUX-CI
  申请人：ARCO CHEM TECH

  公开号：WO2004000794A1

  公开（公告）日：2003-12-31

  Allyl carbamates are disclosed. The allyl carbamates are prepared by reacting an isocyanate with an allylic alcohol or alkoxylated allylic alcohol. Suitable isocyanates are selected from hexamethylene diisocyanate (HDI), HDI biuret, dimer, HDI trimer, HDI allophanate, isophorone diisocyanate (IPDI), IPDI trimer, IPDI allophanate, bis(isocyanatocyclohexyl)methane, and mixtures thereof. The allyl carbamates have at least two allyl functional groups per molecule. UV-curable and air-drying coatings formulated from the allyl carbamates show excellent chemical resistance and physical properties.

  本文介绍了烯丙基氨基甲酸酯。烯丙基氨基甲酸酯是通过将异氰酸酯与烯丙醇或烯丙基醚化醇反应制备而成。适用的异氰酸酯包括己二酸二异氰酸酯（HDI）、HDI双脲、二聚体、HDI三聚体、HDI异氰酸酯、异佛冬烯二异氰酸酯（IPDI）、IPDI三聚体、IPDI异氰酸酯、双（异氰酸基环己基）甲烷以及其混合物。烯丙基氨基甲酸酯每个分子至少具有两个烯丙基官能团。从烯丙基氨基甲酸酯配制的UV固化和空气干燥涂料表现出优异的化学耐受性和物理性能。
• Ultraviolet radiation-curable coatings for optical fibers
  申请人：Borden, Inc.

  公开号：US05352712A1

  公开（公告）日：1994-10-04

  Ultraviolet radiation-curable primary and secondary coating compositions for optical fibers are disclosed. The primary coatings comprise a hydrocarbon polyol-based reactively terminated aliphatic urethane oligomer; a hydrocarbon monomer terminated with at least one end group capable of reacting with the terminus of the oligomer; and an optional photoinitiator. The secondary coatings comprise a polyester and/or polyether-based aliphatic urethane reactively terminated oligomer; a hydrocarbonaceous viscosity-adjusting component capable of reacting with the reactive terminus of (I); and an optional photoinitiator. Also disclosed are optical fibers coated with the secondary coating alone or with the primary and secondary coatings of the invention.

  本发明公开了用于光纤的紫外线辐射可固化的一次和二次涂层组合物。一次涂层包括一种基于碳氢化合物聚醇的反应性端基脂肪族脲聚合物；一种以至少一种末端基团结束的碳氢化合物单体，其能够与寡聚物的端点发生反应；以及可选的光引发剂。二次涂层包括一种基于聚酯和/或聚醚的脂肪族脲反应性端基寡聚物；一种碳氢化粘度调节组分，其能够与(I)的反应性端点发生反应；以及可选的光引发剂。本发明还公开了仅具有二次涂层或具有本发明的一次和二次涂层的光纤。
• New mandelic acid derivatives and their use as thrombin inhibitors
  申请人：Inghardt Tord

  公开号：US20070218136A1

  公开（公告）日：2007-09-20

  There is provided a compound of formula (I) wherein R a , R 1 , R 2 , Y and R 3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants.

  提供了一种化合物，其化学式为（I），其中Ra，R1，R2，Y和R3具有描述中给出的含义以及其药物可接受的衍生物（包括前药），这些化合物和衍生物可用作竞争性蛋白酶抑制剂，如凝血酶，因此特别用于治疗需要抑制凝血酶的情况（例如血栓形成）或作为抗凝剂。
• Mandelic acid derivatives and their use as thrombin inhibitors
  申请人：Inghardt Tord

  公开号：US20080090800A1

  公开（公告）日：2008-04-17

  There is provided a compound of formula (I) wherein R a , R 1 , R 2 , Y and R 3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants.

  提供了一个化合物的公式（I），其中Ra，R1，R2，Y和R3具有描述中给出的含义，以及其药学上可接受的衍生物（包括前药），这些化合物和衍生物可用作具有竞争性的胰蛋白酶类蛋白酶抑制剂的作用，例如凝血酶，因此特别适用于治疗需要抑制凝血酶的情况（例如血栓形成）或作为抗凝剂。