2-Pyridineselenol, 1-oxide | 88892-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Pyridineselenol, 1-oxide
• 英文别名: 2-selenopyridine-1-oxide；2-selenopyridine-N-oxide；2-Seleno-pyridin-N-oxid；2-Selenopyridin-N-oxyd
• CAS: 88892-01-7
• 化学式: C₅H₅NOSe
• 分子量: 174.061
• InChiKey: DRPGKRSXDKTLHK-UHFFFAOYSA-N

物化性质

• 熔点：
  72.5-73.0 °C(Solv: ethanol (64-17-5))
• 沸点：
  446.9±18.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.15
• 重原子数：
  8.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.94
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2-Pyridineselenol, 1-oxide 生成
  参考文献：
  名称：

  HENDERSON, R.;ROTHGERY, E. F.;SCHROEDER, H. A.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴吡啶-1-氧化物 在 sodium tetrahydroborate 、 selenium 作用下， 以 乙醇 为溶剂， 反应 1.5h， 生成 2-Pyridineselenol, 1-oxide
  参考文献：
  名称：

  Development of a novel antidiabetic zinc complex with an organoselenium ligand at the lowest dosage in KK-Ay mice

  摘要：

  Diabetes mellitus (DM) is a considerably diagnosed metabolic disease and a serious problem worldwide. We prepared various zinc complexes and studied their potential for use as new antidiabetic agents. In this study, we synthesized a seleniferous zinc complex, di(2-selenopyridine-N-oxidato)zinc(II) ([ZPS]) that has a Zn(Se2O2) coordination mode. Analyses of structure-activity relationships between its insulin-like activity and the coordination mode of [ZPS]-related complexes showed that it had high insulin-like activity. Hypoglycemic effects of [ZPS] on type 2 diabetic KK-A(y) mice were exerted at the lowest dose administered (1.25-2.5 mg Zn/kg body weight), unlike previously synthesized zinc complexes. Furthermore, [ZPS] afforded us a new advantage; we were able to investigate the tissue distribution of the ligand by measuring the amount of selenium in the organs of [ZPS]-treated mice. Gastrointestinal absorption and tissue penetration of zinc derived from [ZPS] in ddY mice, which was monitored using an isotope tracer technique, was significantly increased compared to that of ZnCl2. These results suggest that [ZPS] has superior antidiabetic effects compared to previously reported zinc complexes, and is thus a potential novel antidiabetic agent that facilitates the possibility of organoselenium ligands as new metal delivery systems for treating DM. (c) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2012.12.008

文献信息

• Cadmium(II) and Nickel(II) 1-Oxypyridyl-2-Selenolates: Synthesis and Molecular and Crystal Structures
  作者：R. K. Askerov、A. M. Magerramov、Zh. V. Matsulevich、V. K. Osmanov、G. N. Borisova、V. N. Khrustalev、S. A. Zalepkina、V. F. Smirnov、A. V. Borisov

  DOI：10.1134/s1070328419030011

  日期：2019.5

  AbstractCadmium (C20H16Cd2N4O4Se4) (I) and nickel (C10H8N2NiO2Se2) (II) selenolates are synthesized by the exchange reactions of sodium 1-oxypyridyl-2-selenolate and cadmium(II) and nickel(II) chlorides. The molecular and crystal structures of the complexes are determined by X-ray structure analysis (CIF files CCDC nos. 1585246 (I) and 1585251 (II)). Complex I forms a centrosymmetric dimer in which the coordination

  摘要通过1-氧吡啶基-2-钠的交换反应合成硒化镉（C 20 H 16 Cd 2 N 4 O 4 Se 4）（I）和镍（C 10 H 8 N 2 NiO 2 Se 2）（II）硒酸盐。硒酸盐和镉（II）以及镍（II）氯化物。配合物的分子和晶体结构是通过X射线结构分析确定的（CIF文件CCDC号1585246（I）和1585251（II））。复杂我形成一个中心对称的二聚体，其中镉原子的配位多面体为扭曲的三角双锥体，硒原子呈反式构型。包含溶剂化物C 2 H 5 OH分子的配合物II具有正方形结构并且是单体。与络合物I不同，在络合物II中，配体的硒原子呈顺式构型。配合物I和II中的晶体堆积是由弱分子间氢键C–H···O和C–H···Se形成的。
• Arvanitis, Georgia M.; Berardini, Michael E.; Acton, Thomas B., Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 82, # 1-4, p. 127 - 136
  作者：Arvanitis, Georgia M.、Berardini, Michael E.、Acton, Thomas B.、Dumas, Philip E.

  DOI：——

  日期：——