3-ethoxy-4,5α-epoxy-17-methyl-morphin-7-en-6α-ol; hydrochloride dihydrate | 6746-59-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 3-ethoxy-4,5α-epoxy-17-methyl-morphin-7-en-6α-ol; hydrochloride dihydrate
• 英文别名: 3-Aethoxy-4,5α-epoxy-17-methyl-morphin-7-en-6α-ol; Hydrochlorid-Dihydrat；(4R,4aR,7S,7aR,12bS)-9-ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol;hydrate;hydrochloride
• CAS: 6746-59-4
• 化学式: C₁₉H₂₃NO₃*ClH*2H₂O
• 分子量: 385.888
• InChiKey: KAKUSMUSYSCWSI-JEWITJNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.49
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  42.9
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 包装等级：
  III
• 危险类别：
  6.1(b)
• 危险品运输编号：
  UN 1544

文献信息

• ORALLY DISINTEGRATING TABLET
  申请人：Sanwa Kagaku Kenkyusho Co., Ltd

  公开号：EP3023109A1

  公开（公告）日：2016-05-25

  Disclosed is an orally disintegrating tablet including: (a) an active ingredient; (b) a starch with an amylose content of 20% by mass to 30% by mass and a degree of gelatinization of less than 10%; and (c) at least one inorganic excipient selected from the group consisting of magnesium silicate, calcium silicate, and synthetic hydrotalcite. The orally disintegrating tablet is a single-layer tablet or a dry-coated tablet having an inner core and an outer layer. The orally disintegrating tablet as a single-layer tablet or the outer layer of the orally disintegrating tablet as a dry-coated tablet has a crystalline cellulose content of 0% by mass to 5% by mass.

  本发明公开了一种口腔崩解片剂，包括：(a)活性成分；(b)淀粉含量为 20% 至 30%，糊化度低于 10%的淀粉；以及(c)至少一种无机赋形剂，该赋形剂选自硅酸镁、硅酸钙和合成水滑石组成的组。口腔崩解片是具有内核和外层的单层片剂或干包衣片剂。作为单层片剂的口腔崩解片或作为干包衣片剂的口腔崩解片的外层的结晶纤维素含量为 0%（质量分数）至 5%（质量分数）。
• Orally Disintegrating Tablet
  申请人：SANWA KAGAKU KENKYUSHO CO., LTD.

  公开号：US20160136091A1

  公开（公告）日：2016-05-19

  Disclosed is an orally disintegrating tablet including: (a) an active ingredient; (b) a starch with an amylose content of 20% by mass to 30% by mass and a degree of gelatinization of less than 10%; and (c) at least one inorganic excipient selected from the group consisting of magnesium silicate, calcium silicate, and synthetic hydrotalcite. The orally disintegrating tablet is a single-layer tablet or a dry-coated tablet having an inner core and an outer layer. The orally disintegrating tablet as a single-layer tablet or the outer layer of the orally disintegrating tablet as a dry-coated tablet has a crystalline cellulose content of 0% by mass to 5% by mass.