bis(nicotinato)(triphenyl)antimony(V) | 741687-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: bis(nicotinato)(triphenyl)antimony(V)
• 英文别名: triphenylantimony bis(nicotinate)；[triphenyl(pyridine-3-carbonyloxy)-λ5-stibanyl] pyridine-3-carboxylate
• CAS: 741687-05-8
• 化学式: C₃₀H₂₃N₂O₄Sb
• 分子量: 597.274
• InChiKey: CSXMGJYADYCRIZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  pentaphenylantimony 、 bis(nicotinato)(triphenyl)antimony(V) 以 苯 为溶剂， 以91%的产率得到tetraphenylantimony nicotinate
  参考文献：
  名称：

  Synthesis and Structure of Tetraphenylantimony Nicotinate

  摘要：

  Tetraphenylantimony nicotinate was prepared in 91% yield by reaction of pentaphenylantimony with triphenyl antimony bis(nicotinate) in toluene. Triphenylantimony bis(nicotinate), in turn, was prepared in 87% yield by oxidative addition of pyridine-3-carboxylic acid to triphenylstibine in ether in the presence of hydrogen peroxide. The structure of tetraphenyl antimony nicotinate was determined by single-crystal X-ray diffraction. The Sb atom has a distorted trigonal bipyramidal coordination surrounding with the carboxy group in the axial position. The Sb-C distances are 2.118(1), 2.121(1), 2.130(1), and 2.170(1) Angstrom, and the Sb-O distance is 2.268(1) Angstrom. There is an intramolecular contact between the Sb atom and the carbonyl O atom [3.363(1) Angstrom].

  DOI：

  10.1023/b:rugc.0000025501.29625.ff
• 作为产物：
  描述：

  烟酸 、 三苯基锑 在 hydrogen peroxide 作用下， 以 乙醚 、 水 为溶剂， 以87%的产率得到bis(nicotinato)(triphenyl)antimony(V)
  参考文献：
  名称：

  Synthesis and Structure of Tetraphenylantimony Nicotinate

  摘要：

  Tetraphenylantimony nicotinate was prepared in 91% yield by reaction of pentaphenylantimony with triphenyl antimony bis(nicotinate) in toluene. Triphenylantimony bis(nicotinate), in turn, was prepared in 87% yield by oxidative addition of pyridine-3-carboxylic acid to triphenylstibine in ether in the presence of hydrogen peroxide. The structure of tetraphenyl antimony nicotinate was determined by single-crystal X-ray diffraction. The Sb atom has a distorted trigonal bipyramidal coordination surrounding with the carboxy group in the axial position. The Sb-C distances are 2.118(1), 2.121(1), 2.130(1), and 2.170(1) Angstrom, and the Sb-O distance is 2.268(1) Angstrom. There is an intramolecular contact between the Sb atom and the carbonyl O atom [3.363(1) Angstrom].

  DOI：

  10.1023/b:rugc.0000025501.29625.ff

文献信息

• Synthesis, characterization and antileishmanial studies of some bioactive heteroleptic pentavalent antimonials
  作者：Rabia Mushtaq、Muhammad Khawar Rauf、Michael Bolte、Akhtar Nadhman、Amin Badshah、Muhammad Nawaz Tahir、Masoom Yasinzai、Khalid Mohammed Khan

  DOI：10.1002/aoc.3606

  日期：2017.5

  between trigonal bipyramidal and square pyramidal. The antileishmanial activity was assessed against Leishmania tropica KWH23, and also human macrophages were used to measure the cytotoxicity of these complexes. The IC50 of the antimonials 1–9 indicates their efficaciousness as compared with the standard antimonial drug used. The significant activity of complex 1 assumes that greater multitude of interactions

  在追求安全的药物候选的寄生疾病如利什曼病，一系列所述类型的杂五价锑的[R的处理3的Sb（O 2 CR'）2 ]（1 - 9）已经被合成，并使用元素分析（ CHN），傅里叶变换红外光谱和多核（1 H和13 C）NMR光谱。研究的羧酸盐主要是取代的苯甲酸酯，带有一些具有乙酰或尼古丁配体的配合物。[Sb（C 6 H 5）3（o -NH 2 C 6 H[4 COO）2 ]（1）和[Sb（C 6 H 5）3（3,5-Cl 2 C 6 H 3 COO）2 ]（4）被确定为基本上具有Sb（V）中心的单体，并显示采用介于三角形双锥体和正方形锥体之间的几何形状。评估了抗热带利什曼原虫KWH23的抗菌活性，并且还使用人类巨噬细胞来测量这些复合物的细胞毒性。锑1 – 9的IC 50表示与使用的标准锑药相比，它们的功效。配合物1的显着活性假定大量的相互作用是抗刀刃活性增强的原因。细胞毒性结果表明，即使在低浓度下，