2P8Dbq9WL3 | 1058185-02-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 2P8Dbq9WL3
• 英文别名: [(1S,9S,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-yl]oxymethyl propan-2-yl carbonate
• CAS: 1058185-02-6
• 化学式: C₂₁H₂₉NO₄
• 分子量: 359.5
• InChiKey: XUUSKRFBAUMDGN-LMNJBCLMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ORALLY BIOAVAILABLE PRODUCTS OF (+)-3-HYDROXYMORPHINAN FOR PARKINSON'S DISEASE PREVENTION OR TREATMENT
  申请人：Lee Jinhwa

  公开号：US20100113500A1

  公开（公告）日：2010-05-06

  The present invention is directed to a novel prodrug of (+)-3-hydroxymorphinan compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the same, and its use for preventing or treating Parkinson's disease.

  本发明涉及一种新型的(+)-3-羟基吗啡纳化合物的前药，其化学式为(I)，或其药学上可接受的盐，以及其制备方法和用于预防或治疗帕金森病的用途。
• MORPHINAN-DERIVATIVES FOR TREATING DIABETES AND RELATED DISORDERS
  申请人：Deutsche Diabetes-Forschungsgesellschaft e. V.

  公开号：EP2747754B1

  公开（公告）日：2017-04-05
• Morphinan-derivatives for treating diabetes and related disorders
  申请人：Lammert Eckhard

  公开号：US20150087669A1

  公开（公告）日：2015-03-26

  The invention relates to a morphinan-derivative that targets NMDA receptors on pancreatic islets and has the general formula (I) wherein R 1 is selected from —OH, —CO 2 H, —R 0 , —OR 0 , —OC(═O)R 0 , —OC(═O)OR 0 or —OC(═O)NHR 0 ; and R 2 is selected from —H, —R 0 , —C(═O)R 0 , —C(═O)OR 0 , —C(═O)NHR 0 or —C(═NH)—NH—C(═NH)—NH 2 ; wherein R 0 is in each case independently selected from —C 1 -C 6 -alkyl, -aryl, -heteroaryl, —C 1 -C 6 -alkyl-aryl or —C 1 -C 6 -alkyl-heteroaryl, in each case independently unsubstituted or substituted; or its physiologically acceptable salt and/or stereoisomer, including mixtures thereof in all ratios, for use in the treatment of a disease or condition, where the disease or condition is insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus, obesity, and/or diabetic nephropathy.
• US8178551B2
  申请人：——

  公开号：US8178551B2

  公开（公告）日：2012-05-15
• US9370511B2
  申请人：——

  公开号：US9370511B2

  公开（公告）日：2016-06-21