6-[5-(7-Acetyloxy-6-chloro-8-fluoro-2-oxochromen-3-yl)thiophen-2-yl]hexanoic acid | 1246892-13-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6-[5-(7-Acetyloxy-6-chloro-8-fluoro-2-oxochromen-3-yl)thiophen-2-yl]hexanoic acid
• CAS: 1246892-13-6
• 化学式: C₂₁H₁₈ClFO₆S
• 分子量: 452.888
• InChiKey: QFNOXQZRYVFDNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• REACTIVE COUMARIN DERIVATIVES AND THEIR USE IN CELLULAR ANALYSES
  申请人：DIWU Zhenjun

  公开号：US20110318772A1

  公开（公告）日：2011-12-29

  Chemically reactive 7-hydroxycoumarin derivatives and their application for analyzing cell function, for example in combination with additional fluorescent labels. The coumarin derivatives exhibit a strong absorption at 405 nm and high fluorescence quantum yields.

  7-羟基香豆素衍生物在分析细胞功能方面的应用，例如与额外的荧光标记物结合。香豆素衍生物在405纳米处具有强烈吸收和高荧光量子产率。
• Reactive Heterocycle-Substituted 7-Hydroxycoumarins and Their Conjugates
  申请人：Diwu Zhenjun

  公开号：US20100255504A1

  公开（公告）日：2010-10-07

  Chemically-reactive, water-soluble, heterocycle-substituted 7-hydroxycoumarin dyes, their bioconjugates and uses are described. The conjugates derived from reactive heterocycle-substituted 7-hydroxycoumarin dyes are used for analyzing biological compounds. These heterocycle-substituted 7-hydroxycoumarin dyes are particularly useful as fluorescent labels for biopolymer detection reagents, such as antibodies or nucleic acid probes. The dye-antibody conjugates of the invention are particularly useful for analyzing analytes using a flow cytometer equipped with a violet laser as an excitation source due to their strong absorption at 405 nm and high fluorescence quantum yield.

  本文介绍了化学反应性、水溶性、杂环取代的7-羟基香豆素染料及其生物共轭物和用途。从反应性杂环取代的7-羟基香豆素染料衍生的共轭物被用于分析生物化合物。这些杂环取代的7-羟基香豆素染料特别适用于生物聚合物检测试剂的荧光标记，例如抗体或核酸探针。本发明的染料-抗体共轭物特别适用于使用紫外激光器作为激发源的流式细胞仪分析分析物，因为它们在405 nm处具有强烈的吸收和高荧光量子产率。
• US8318953B2
  申请人：——

  公开号：US8318953B2

  公开（公告）日：2012-11-27
• US8431416B2
  申请人：——

  公开号：US8431416B2

  公开（公告）日：2013-04-30