N,N',N'',N'''-((butane-1,4-diylbis(azanetriyl))tetrakis(propane-3,1-diyl))tetrakis(hydrazinecarbothioamide) | 1341222-06-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N',N'',N'''-((butane-1,4-diylbis(azanetriyl))tetrakis(propane-3,1-diyl))tetrakis(hydrazinecarbothioamide)
• CAS: 1341222-06-7
• 化学式: C₂₀H₄₈N₁₄S₄
• 分子量: 612.959
• InChiKey: SJYQQPGLEOQYHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.72
• 重原子数：
  38.0
• 可旋转键数：
  21.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  206.8
• 氢给体数：
  12.0
• 氢受体数：
  10.0

反应信息

• 作为产物：
  描述：

  二硫化碳 、 N,N,N,N-四(3-氨基丙基)-1,4-丁二胺 在 sodium hydroxide 、 sodium monochloroacetic acid 、 盐酸 、 一水合肼 作用下， 以 水 为溶剂， 反应 30.0h， 以65%的产率得到N,N',N'',N'''-((butane-1,4-diylbis(azanetriyl))tetrakis(propane-3,1-diyl))tetrakis(hydrazinecarbothioamide)
  参考文献：
  名称：

  Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity

  摘要：

  First-generation ferrocenylthiosemicarbazone metallodendrimers based on a poly(propyleneimine) dendrimer scaffold were synthesised with ferrocenylthiosemicarbazone moieties conjugated to the periphery of the branched polyamine scaffolds. The compounds were characterised by NMR and IR spectroscopy, elemental analysis and ESI-mass spectrometry. These new complexes were evaluated as bioorganometallic antimalarial agents against the Plasmodium falciparum chloroquine-resistant W2 strain. In vitro antiplasmodial assays of the dendritic ferrocenylthiosemicarbazones against the malaria parasite P. falciparum show increased efficacy compared to the precursor non-conjugated thioesters. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2011.07.028