7α-methyl-17α-ethynyl-11α,15β,17β-trihydroxy-19-norandrost-5(10)-en-3-one | 1155267-22-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7α-methyl-17α-ethynyl-11α,15β,17β-trihydroxy-19-norandrost-5(10)-en-3-one
• 英文别名: 11α,15β-dihydroxytibolone；7α-methyl-17α-ethynl-11α,15β,17β-trihydroxy-19-norandrost-5(10)-en-3-one；(7R,8R,9S,11R,13S,14S,15R,17R)-17-ethynyl-11,15,17-trihydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 1155267-22-3
• 化学式: C₂₁H₂₈O₄
• 分子量: 344.451
• InChiKey: LHAGAJWRQRSJFP-VZKPGFRCSA-N

物化性质

• 熔点：
  208-210 °C
• 沸点：
  531.9±50.0 °C(predicted)
• 密度：
  1.27±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  替勃龙 在 Cunninghamella elegans (ATCC 10028b) 作用下， 以 丙酮 为溶剂， 反应 144.0h， 生成 7α-methyl-17α-ethynyl-17β-hydroxy-19-norandrosta-1,4-dien-3-one 、 7α-methyl-17α-ethynyl-11α,15β,17β-trihydroxy-19-norandrost-5(10)-en-3-one 、 (7alpha,17alpha)-17,19-二羟基-7-甲基-19-去甲孕甾-4-烯-20-炔-3-酮
  参考文献：
  名称：

  Method of producing tibolone metabolites by fermentation with Rhizopus stolonifer

  摘要：

  一种生产地泼龙代谢产物的新方法，包括将地泼龙与根霉菌（ATCC 12938）发酵，从而形成Δ4-地泼龙（C21H28O2）、6β-羟基地泼龙和15β-羟基地泼龙（C21H28O3）。

  公开号：

  US08148556B2

文献信息

• Alpha-glucosidase and tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones
  作者：M. Iqbal Choudhary、S. Adnan Ali Shah、Atta-ur-Rahman、Shamsun-Nahar Khan、Mahmud Tareq Hassan Khan

  DOI：10.1016/j.steroids.2010.05.017

  日期：2010.12

  Sixteen new and one known metabolites 4-20 were obtained by incubation of tibolone (1) and hydroxytibolones (2 and 3) with various fungi. Their structures were elucidated by means of a homo and heteronuclear 2D NMR and by HREI-MS techniques. The relative stereochemistry was deduced by 2D NOESY experiment. Metabolites of tibolone (1) exhibited significant inhibitory activities against alpha-glucosidase and tyrosinase enzymes. Hydroxylations at C-6, C-10, C-11, C-15 positions and alpha,beta-unsaturation at C-1/C-2, C-4/C-5 showed potent inhibitory activities against these enzymes. (C) 2010 Elsevier Inc. All rights reserved.