3-(Acetyloxy)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl propanoate | 66640-99-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 3-(Acetyloxy)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl propanoate
• 英文别名: [(4R,4aR,7S,7aR,12bS)-9-acetyloxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] propanoate
• CAS: 66640-99-1
• 化学式: C₂₂H₂₅NO₅
• 分子量: 383.4
• InChiKey: JDTRGWXTYWXUHP-CLTUZACYSA-N

物化性质

• 沸点：
  503.7±50.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HALOGENATED DERIVATIVES OF MORPHINANS AND USES THEREOF
  申请人：Xalud Therapeutics, Inc.

  公开号：EP3723749A1

  公开（公告）日：2020-10-21
• COMPOUND DELIVERY SYSTEMS AND METHODS OF PRODUCTION
  申请人：Golfetto Michael

  公开号：US20220008348A1

  公开（公告）日：2022-01-13

  A delivery composition including a plurality of first nanoparticle excipients each containing an active compound pharmaceutical agent and a plurality of second nanoparticle excipients each containing a modulating agent.
• [EN] HALOGENATED DERIVATIVES OF MORPHINANS AND USES THEREOF<br/>[FR] DÉRIVÉS HALOGÉNÉS DE MORPHINANES ET LEURS UTILISATIONS
  申请人：XALUD THERAPEUTICS INC

  公开号：WO2019118583A1

  公开（公告）日：2019-06-20

  The present invention encompasses improved morphian compositions and methods of use of the improved compositions for modulating neuropathic pain, opioid- induced glial activation, or a combination thereof beyond what is currently known in the art. The methods involve administering the compound of Formula I to a subject.