(+)-dyfonate | 62680-03-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+)-dyfonate
• 英文别名: S-(+)-fonofos；O-ethyl S-phenyl ethylphosphonodithioate；(S)-Ethylphosphonodithioic acid O-ethyl S-phenyl ester；ethoxy-ethyl-phenylsulfanyl-sulfanylidene-λ5-phosphane
• CAS: 62680-03-9
• 化学式: C₁₀H₁₅OPS₂
• 分子量: 246.334
• InChiKey: KVGLBTYUCJYMND-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-2790乳剂 生成 (+)-dyfonate 、 (-)-dyfonate
  参考文献：
  名称：

  Enantioselective acetylcholinesterase inhibition of the organophosphorous insecticides profenofos, fonofos, and crotoxyphos

  摘要：

  摘要 许多有机磷杀虫剂（OPs）都是手性化合物，但它们在环境转归和影响方面的对映体选择性却很少得到关注。在本研究中，我们分离了三种有机磷杀虫剂（丙溴磷、福诺磷和克磷）的对映体，并评估了它们抑制乙酰胆碱酯酶（AChE）的对映选择性。对映体和外消旋体对乙酰胆碱酯酶的抑制作用是在水生无脊椎动物大型蚤（Daphnia magna）和日本青鳉（Oryzias latipes）体内以及电鳗（Electrophorus electricus）和人类重组乙酰胆碱酯酶体外进行测定的。总体结果显示，不同物种的 AChE 酶之间的敏感性不同，酶抑制的对映体选择性也不同。丙溴磷的(-)-对映体在体内对乙酰胆碱酯酶的抑制作用比(-)-对映体强4.3-8.5倍，而(-)-福诺磷比相应的(+)-对映体强2.3-29倍。克芜踪的(+)-对映体对乙酰胆碱酯酶的抑制作用是(-)-对映体的1.1-11倍。相反，体外研究结果显示，(+)-丙溴磷的抑制作用是(-)-对映体的2.6-71.8倍，而(-)-克罗托磷的活性是(+)-对映体的1.6-1.9倍。在体内和体外试验中观察到的对映体选择性方向相反，这表明在摄取、生物转化或消除等毒力作用过程中存在对映体选择性。本研究结果提供了手性 OPs 在抑制非目标生物 AChE 过程中的对映体选择性证据，并表明在评估这些手性农药的环境风险时需要单独考虑对映体。

  DOI：

  10.1897/07-001r.1

文献信息

• METHOD FOR PREPARING EMULSIFIABLE SOLID AGROCHEMICAL COMPOSITION CONTAINING INORGANIC SALT
  申请人：Kyung Nong Corporation

  公开号：EP2868195A1

  公开（公告）日：2015-05-06

  The present invention relates to a method for preparing an emulsifiable solid agrochemical composition which contains an inorganic salt and which can be used as an agrochemical emulsion. The preparation method according to the present invention has the advantage that, because there is no need for a step of heating and evaporating a solvent or water, it is possible to use a surfactant or active ingredient that has a low boiling point or breaks down drastically at a high temperature, and, due to the solid-phase form, it is possible to minimize the amount that sticks to a container as there is no need to use a special synthetic resin or glass bottle that entails high packaging costs. Also, a granular emulsifier (EG) or a powdery emulsifier (EP) produced by means of the method according to the present invention can be further diluted in water before use so as to form common emulsion (EC) emulsified particles (0.1 µm to 100 µm) to transparent microemulsion particles (0.001 µm to 1 µm or 1 nm to 1000 nm), and thus the emulsion size can be freely modified so as to maximise the activity of the agrochemical component in accordance with the characteristics of a crop or an insect pest.

  本发明涉及一种可乳化的固体农用化学品组合物的制备方法，该组合物含有一种无机盐，可用作农用化学品乳剂。根据本发明的制备方法具有以下优点：由于不需要加热和蒸发溶剂或水的步骤，因此可以使用低沸点或在高温下急剧分解的表面活性剂或活性成分；由于是固相形式，因此可以最大限度地减少粘附在容器上的量，因为不需要使用需要高昂包装成本的特殊合成树脂或玻璃瓶。此外，根据本发明的方法生产的颗粒状乳化剂（EG）或粉末状乳化剂（EP）在使用前可进一步用水稀释，以形成普通乳液（EC）乳化颗粒（0.1 微米至 100 微米）到透明微乳液颗粒（0.001 微米至 1 微米或 1 纳米至 1000 纳米），因此可根据作物或害虫的特性自由改变乳液大小，以最大限度地提高农用化学品成分的活性。
• Method for Preparing Emulsifiable Solid Agrochemical Composition Containing Inorganic Salt
  申请人：Kyung Nong Corporation

  公开号：US20150189886A1

  公开（公告）日：2015-07-09

  The present invention relates to a method for preparing an emulsifiable solid agrochemical composition which contains an inorganic salt and which can be used as an agrochemical emulsion. The preparation method according to the present invention has the advantage that, because there is no need for a step of heating and evaporating a solvent or water, it is possible to use a surfactant or active ingredient that has a low boiling point or breaks down drastically at a high temperature, and, due to the solid-phase form, it is possible to minimise the amount that sticks to a container as there is no need to use a special synthetic resin or glass bottle that entails high packaging costs. Also, a granular emulsifier (EG) or a powdery emulsifier (EP) produced by means of the method according to the present invention can be further diluted in water before use so as to form common emulsion (EC) emulsified particles (0.1 μm to 100 μm) to transparent microemulsion particles (0.001 μm to 1 μm, or 1 nm to 1000 nm), and thus the emulsion size can be freely modified so as to maximise the activity of the agrochemical component in accordance with the characteristics of a crop or an insect pest.
• US9801382B2
  申请人：——

  公开号：US9801382B2

  公开（公告）日：2017-10-31