1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methan | 1061330-67-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methan
• 英文别名: [4-(Diethylamino)-2-hydroxyphenyl]-(2-methylphenyl)methanone
• CAS: 1061330-67-3
• 化学式: C₁₈H₂₁NO₂
• 分子量: 283.37
• InChiKey: KWSKBDIICWHFPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methan 、 间苯二酚 在 甲烷磺酸 作用下， 反应 5.0h， 以9%的产率得到
  参考文献：
  名称：

  Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

  摘要：

  We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.065
• 作为产物：
  描述：

  (4-(diethylamino)-2-methoxyphenyl)(o-tolyl)methanone 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以61%的产率得到1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methan
  参考文献：
  名称：

  Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

  摘要：

  We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.065

文献信息

• UV LIGHT-PROTECTIVE AGENT BASED ON MIXED INORGANIC-ORGANIC SYSTEMS
  申请人：Lehmann Stephan

  公开号：US20100135939A1

  公开（公告）日：2010-06-03

  The present invention relates to photoprotective preparations, in particular in the field of cosmetics, based on inorganic-organic mixed systems. The present invention relates in particular to photoprotective preparations comprising nanoparticles of at least one metal derivative, at least one photoprotective compound chemically bonded to these metal derivative nanoparticles, and at least one further organic UV photoprotective agent which is different from the photoprotective compound bonded to the metal derivative nanoparticles.

  本发明涉及无机-有机混合系统的防晒制剂，特别是在化妆品领域。本发明特别涉及包含至少一种金属衍生物纳米粒子、至少一种化学键合到这些金属衍生物纳米粒子上的光保护化合物和至少一种与键合到金属衍生物纳米粒子上的光保护化合物不同的有机紫外线光保护剂的防晒制剂。
• Retinoid-Containing Preparations
  申请人：Ptock Arne

  公开号：US20070202060A1

  公开（公告）日：2007-08-30

  Preparations comprising a. at least one retinoid, b. at least one water-soluble antioxidant, c. at least one oil-soluble antioxidant and d. 0.01 to 10% by weight of at least one UV filter, wherein, in the preparations, per part by weight of retinoid, at least 1 part by weight of one or more water-soluble antioxidants and 0.1 to 100 parts by weight of one or more oil-soluble antioxidants are present, where the content of one or more water-soluble antioxidants is in the range from 0.05 to 0.8% by weight, based on the total amount of the preparations.
• Use of Amphiphilic Copolymers as Solubilising Agents
  申请人：Pierobon Marianna

  公开号：US20080153925A1

  公开（公告）日：2008-06-26

  Solubilizers prepared by polymerizing: (i) at least one first monomer of the general formula (I): wherein R1 and R2 each independently represent H or CH 3 , R3 represents a C 6 -C 10 -aryl or C 7 -C 12 -aralkyl which may be unsubstituted or substituted with one or more C 1 -C 9 -alkyl and/or C 1 -C 5 -alkoxy substituents, and n represents an integer from 0 to 100; and (ii) at least one second monomer selected from the group consisting of N-vinylamides, N-vinyllactams, N-vinylimines, N-vinylamines having 2 to 15 carbon atoms, and mixtures thereof; and methods of solubilizing active ingredients by combining them with such a solubilizer.
• Use of Peroxide Decomposers Method For the Treatment of a Material Other Than the Human Body
  申请人：Kroll Manfred

  公开号：US20080193397A1

  公开（公告）日：2008-08-14

  The invention relates to the use of compounds with certain sulfur and optionally nitrogen atom-containing structures as peroxide decomposers in cosmetic and pharmaceutical agents for treating the skin. The invention also relates to cosmetic and pharmaceutical agents comprising compounds having such structures.
• Isoalkane Mixture, Its Preparation And Use
  申请人：Lange Arno

  公开号：US20080193404A1

  公开（公告）日：2008-08-14

  The present invention relates to an isoalkane mixture, to a method for its preparation and to cosmetic or pharmaceutical compositions which comprise such a mixture.