2-[2,6-di(4-trifluoromethylphenyl)phenyl]-oxazoline | 1383478-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2,6-di(4-trifluoromethylphenyl)phenyl]-oxazoline
• 英文别名: 2-[2,6-Bis[4-(trifluoromethyl)phenyl]phenyl]-4,5-dihydro-1,3-oxazole；2-[2,6-bis[4-(trifluoromethyl)phenyl]phenyl]-4,5-dihydro-1,3-oxazole
• CAS: 1383478-24-7
• 化学式: C₂₃H₁₅F₆NO
• 分子量: 435.369
• InChiKey: BOCVURGFDCVLRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4,5-二氢-2-苯基恶唑 、 对溴三氟甲苯 在 [RhCl2(p-cymene)]2 、 potassium acetate 、 potassium carbonate 、 三苯基膦 作用下， 以 水 为溶剂， 反应 20.0h， 以87%的产率得到2-[2,6-di(4-trifluoromethylphenyl)phenyl]-oxazoline
  参考文献：
  名称：

  Catalytic C–H bond arylation of aryl imines and oxazolines in water with ruthenium(II)-acetate catalyst

  摘要：

  Ruthenium(II)-acetate catalyzed C-H bond activation/diarylations of aryl-aldimines, aryl-ketimines and phenyl-oxazolines with aryl bromides in water are reported. Water strongly favours the catalytic diarylation of aryl-ketimines and phenyl-oxazolines with respect to organic solvent. CD (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.117

文献信息

• Combination of RuCl₃·xH₂O with PEG – a simple and recyclable catalytic system for direct arylation of heteroarenes via C–H bond activation
  作者：Lei Jian、Hai-Yu He、Jin Huang、Qian-Hui Wu、Mao-Lin Yuan、Hai-Yan Fu、Xue-Li Zheng、Hua Chen、Rui-Xiang Li

  DOI：10.1039/c7ra02638b

  日期：——

  A simple and recyclable catalytic system for direct arylation of heteroarenes via C–H bond activation was developed with a relatively inexpensive RuCl3·xH2O as a catalyst and PEG-400 as a green medium without any additive or ligand. This system not only showed excellent functional group compatibility, but also the ratio of mono- to diarylated product was easily regulated by varying the reaction conditions

  通过使用相对便宜的RuCl 3 · x H 2 O作为催化剂和PEG-400作为绿色介质，没有任何添加剂或配体，开发了一种简单且可回收的催化系统，用于通过C–H键活化杂芳烃直接芳基化。该体系不仅显示出优异的官能团相容性，而且通过改变反应条件也很容易调节单芳基化产物与二芳基化产物的比例。而且，该转化可以在空气中进行，并且在0.3mol％的低催化剂负载下可以容易地按比例放大至克级。特别地，在将该催化剂循环六次之后，获得了85％的良好产率。
• Catalytic C–H bond arylation of aryl imines and oxazolines in water with ruthenium(II)-acetate catalyst
  作者：Bin Li、Karthik Devaraj、Christophe Darcel、Pierre H. Dixneuf

  DOI：10.1016/j.tet.2012.03.117

  日期：2012.7

  Ruthenium(II)-acetate catalyzed C-H bond activation/diarylations of aryl-aldimines, aryl-ketimines and phenyl-oxazolines with aryl bromides in water are reported. Water strongly favours the catalytic diarylation of aryl-ketimines and phenyl-oxazolines with respect to organic solvent. CD (C) 2012 Elsevier Ltd. All rights reserved.