(4-chloro-3-cinnolinyl)phenylmethanol | 173415-11-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (4-chloro-3-cinnolinyl)phenylmethanol
• 英文别名: (4-Chlorocinnolin-3-yl)-phenylmethanol
• CAS: 173415-11-7
• 化学式: C₁₅H₁₁ClN₂O
• 分子量: 270.718
• InChiKey: NSXHHKQLNBOEMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-chloro-3-cinnolinyl)phenylmethanol 在 manganese(IV) oxide 作用下， 以 甲苯 为溶剂， 反应 18.0h， 生成 2,3-dihydro-1H-5-phenylcinnolino<3,4-b><1,4>diazepine
  参考文献：
  名称：

  Metallation of diazines XIV. First O-directed metallation of cinnolines. Metallation of 3-, 4-chloro and 3-, 4-methoxycinnolines

  摘要：

  The lithiation of 3-, 4-chloro and 3-, 4-methoxycinnolines was studied and good yields were obtained. When iodine was used as electrophile, 4,8-diiodo or 4,8-iodochloro compounds were prepared. A xanthone and diazepines were synthetized.

  DOI：

  10.1016/0040-4020(95)00835-v
• 作为产物：
  描述：

  4-羟基噌嗪 在 吡啶 、 lithium diisopropyl amide 、 三氯氧磷 作用下， 以 四氢呋喃 、 正己烷 、 氯苯 为溶剂， 反应 5.5h， 生成 (4-chloro-3-cinnolinyl)phenylmethanol
  参考文献：
  名称：

  Metallation of diazines XIV. First O-directed metallation of cinnolines. Metallation of 3-, 4-chloro and 3-, 4-methoxycinnolines

  摘要：

  The lithiation of 3-, 4-chloro and 3-, 4-methoxycinnolines was studied and good yields were obtained. When iodine was used as electrophile, 4,8-diiodo or 4,8-iodochloro compounds were prepared. A xanthone and diazepines were synthetized.

  DOI：

  10.1016/0040-4020(95)00835-v

文献信息

• Metallation of diazines XIV. First O-directed metallation of cinnolines. Metallation of 3-, 4-chloro and 3-, 4-methoxycinnolines
  作者：A. Turck、N. Pié、V. Tallon、G. Quéguiner

  DOI：10.1016/0040-4020(95)00835-v

  日期：1995.11

  The lithiation of 3-, 4-chloro and 3-, 4-methoxycinnolines was studied and good yields were obtained. When iodine was used as electrophile, 4,8-diiodo or 4,8-iodochloro compounds were prepared. A xanthone and diazepines were synthetized.