(8R)-8-[3,5-bis(trifluoromethyl)phenyl]-5-({2-(3-fluoroazetidin-1-yl)-5-[4'-(hydroxymethyl)-4-methoxy-2'-methylbiphenyl-3-yl]pyrimidin-4-yl}methyl)-7-oxa-5-azaspiro[3.4]octan-6-one | 1616347-46-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (8R)-8-[3,5-bis(trifluoromethyl)phenyl]-5-({2-(3-fluoroazetidin-1-yl)-5-[4'-(hydroxymethyl)-4-methoxy-2'-methylbiphenyl-3-yl]pyrimidin-4-yl}methyl)-7-oxa-5-azaspiro[3.4]octan-6-one
• 英文别名: (8R)-8-[3,5-bis(trifluoromethyl)phenyl]-5-({2-(3-fluoroazetidin-1-yl)-5-[4''-(hydroxymethyl)-4-methoxy-2''-methylbiphenyl-3-yl]pyrimidin-4-yl}methyl)-7-oxa-5-azaspiro[3.4]octan-6-one；(8R)-8-[3,5-bis(trifluoromethyl)phenyl]-5-[[2-(3-fluoroazetidin-1-yl)-5-[5-[4-(hydroxymethyl)-2-methylphenyl]-2-methoxyphenyl]pyrimidin-4-yl]methyl]-7-oxa-5-azaspiro[3.4]octan-6-one
• CAS: 1616347-46-6
• 化学式: C₃₇H₃₃F₇N₄O₄
• 分子量: 730.682
• InChiKey: SEEVDVWDMJSSDQ-JGCGQSQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  52
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  88
• 氢给体数：
  1
• 氢受体数：
  14

文献信息

• SPIROCYCLIC CETP INHIBITORS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20150342931A1

  公开（公告）日：2015-12-03

  Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing atherosclerosis. The chemical compounds that are disclosed cholesterol ester transfer protein (CETP) and are expected to have utility in raising HDL-C, lowering LDL-C, and in the treatment and prevention of atherosclerosis.

  具有公式(I)结构的化合物，包括该化合物的药学上可接受的盐，是CETP抑制剂，可以用于提高人体患者的HDL-胆固醇，降低LDL-胆固醇，并用于治疗或预防动脉硬化。这些化学化合物是胆固醇酯转移蛋白（CETP）的抑制剂，预计在提高HDL-C，降低LDL-C以及治疗和预防动脉硬化方面具有用途。
• US9717714B2
  申请人：——

  公开号：US9717714B2

  公开（公告）日：2017-08-01