Fezatione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Fezatione
• 英文别名: 3-[(E)-(4-methylphenyl)methylideneamino]-4-phenyl-1,3-thiazole-2-thione
• 化学式: C₁₇H₁₄N₂S₂
• 分子量: 310.4
• InChiKey: SRANDCPSMJNFCK-WOJGMQOQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  73
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
  申请人：Cai Jianfeng

  公开号：US20150274782A1

  公开（公告）日：2015-10-01

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一种新型类别的抗微生物药物，称为γ-AA肽。当前发明提供了各种类别的γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂质化γ-AA肽。本发明的γ-AA肽被设计为具有抗微生物活性，同时稳定且无毒。γ-AA肽似乎也不会导致被治疗微生物体内微生物产生抗药性。因此，所披露的γ-AA肽可用于治疗与病原微生物相关的各种医疗状况。
• Benzoyl Peroxide Composition, Methods for Making Same, and Pharmaceutical or Cosmetic Formulations Comprising Same, and Uses Thereof
  申请人：Levin Daniel

  公开号：US20120064135A1

  公开（公告）日：2012-03-15

  The present invention relates to the preparation of compositions comprising benzoyl peroxide, with or without other additional active ingredients. The process involves introducing benzoyl peroxide, along with any other active ingredients present, into a fatty substance that contains and protects the ingredients that would otherwise be unstable when in contact with one another. The composition is designed to allow all ingredients to become available for skin contact or skin absorption when the fatty substance softens and/or melts as the composition is applied to the skin. The benzoyl peroxide may be pre-micronized to a particle distribution size of about d 90 of 0.1 to 150 microns, preferably d 90 of 10 to 15 microns. Further, pharmaceutical or cosmetic ingredients may be contained within the fatty substances, with or without, benzoyl peroxide therein or may be present outside of the fatty substance but elsewhere within formulated pharmaceutical or cosmetic products using the active ingredients protected by the fatty substance. These compositions are useful in aqueous-based formulations to treat diseases by topical, transdermal and/or subcutaneous administration.

  本发明涉及制备包含过氧苯甲酰的组合物，可包含其他额外活性成分。该过程涉及将过氧苯甲酰以及其他任何活性成分引入含有并保护这些成分的脂肪物质中，以防止它们在接触时变得不稳定。该组合物设计为在脂肪物质软化和/或融化时，使所有成分可用于皮肤接触或皮肤吸收。过氧苯甲酰可以经预微粒化处理，粒度分布大小约为d90的0.1至150微米，优选d90的10至15微米。此外，医药或化妆品成分可以包含在脂肪物质中，其中可能含有或不含有过氧苯甲酰，或者可能存在于脂肪物质之外，但在使用脂肪物质保护的活性成分的制剂医药或化妆品产品中的其他地方。这些组合物可用于治疗疾病的水基配方，通过局部、经皮和/或皮下给药。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Spray on bandage and drug delivery system
  申请人：3M Innovative Properties Company

  公开号：US20040013629A1

  公开（公告）日：2004-01-22

  The present invention provides novel “patch in a bottle” technology in which a fluid composition, e.g., an aerosol spray, is applied onto a surface as a fluid, but then dries to form a covering element, such as a patch, having a tack free outer surface covering an underlying adhesive that helps adhere the patch to the substrate. The fluid compositions have a unique chemical formulation that allows such composite patches to form in situ. Specifically, the fluid compositions include a tacky component, such as an adhesive, and a film-forming, non-tacky component. The non-tacky and tacky components are selected to be immiscible with each other so that the components undergo phase separation as the fluid composition dries.

  本发明提供了一种新型的“瓶中贴片”技术，其中将流体组成物（例如，气雾剂喷雾）作为流体涂在表面上，但随后干燥形成覆盖元素，例如贴片，其具有无粘性的外表面覆盖底层粘合剂，有助于将贴片粘附到基板上。流体组成物具有独特的化学配方，允许在原位形成这样的复合贴片。具体而言，流体组成物包括粘性组分，例如粘合剂，以及成膜、无粘性组分。非粘性和粘性组分被选择为互不相溶，因此随着流体组成物的干燥，这些组分会发生相分离。
• Improved penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0129284A2

  公开（公告）日：1984-12-27

  Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at selected levels in combination with certain C3-C4 diols or a 1-substituted azacycloalkyl-2-one. This composition provides marked transepidermal and percutaneous delivery of the selected pharmaceutically-active agent. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.

  本发明公开了含有一种药物活性剂和渗透增强剂 1-十二烷基氮杂环庚烷-2-酮的改良外用药物组合物。这种药剂与某些 C3-C4 二醇或 1-取代偶氮环烷基-2-酮结合使用时，可达到选定的水平。这种组合物能明显地经皮和经皮给药。此外，还公开了一种全身或局部治疗对所选活性剂有反应的某些病理和病症的方法。