N-[4-hydroxy-3-(phenylsulfonyl)phenyl]-4-methylbenzenesulfonamide | 321577-44-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-hydroxy-3-(phenylsulfonyl)phenyl]-4-methylbenzenesulfonamide
• 英文别名: N-[3-(benzenesulfonyl)-4-hydroxyphenyl]-4-methylbenzenesulfonamide
• CAS: 321577-44-0
• 化学式: C₁₉H₁₇NO₅S₂
• 分子量: 403.48
• InChiKey: HLPRLUWAEPNRMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(4-羟基苯基)-4-甲基苯磺酰胺 、 sodium benzenesulfonate 以 乙腈 为溶剂， 以55%的产率得到N-[4-hydroxy-3-(phenylsulfonyl)phenyl]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Electrochemical oxidation of aminophenols in the presence of benzenesulfinate

  摘要：

  The anodic oxidation of aminophenols and their amino-protected derivatives was investigated by using cyclic voltammetry and preparative electrolysis methods. The results showed that like the catechols the amino-protected aminophenol could also undergo Michael addition, and that the benzenesulfonate group was regioselectively introduced at the meta-position of the amino group. In contrast, the expected products were not formed from the oxidation of unprotected aminophenols. Finally, a reaction mechanism is proposed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.005

文献信息

• Electrochemical oxidation of aminophenols in the presence of benzenesulfinate
  作者：Huan-Lan Xiao、Cheng-Wen Yang、Ni-Tao Zhang、Cheng-Chu Zeng、Li-Ming Hu、Hong-Yu Tian、R. Daniel Little

  DOI：10.1016/j.tet.2012.11.005

  日期：2013.1

  The anodic oxidation of aminophenols and their amino-protected derivatives was investigated by using cyclic voltammetry and preparative electrolysis methods. The results showed that like the catechols the amino-protected aminophenol could also undergo Michael addition, and that the benzenesulfonate group was regioselectively introduced at the meta-position of the amino group. In contrast, the expected products were not formed from the oxidation of unprotected aminophenols. Finally, a reaction mechanism is proposed. (C) 2012 Elsevier Ltd. All rights reserved.