(E)-2-((E)-3-phenylallylidene)hydrazine-1-carboximidamide | 5382-85-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2-((E)-3-phenylallylidene)hydrazine-1-carboximidamide
• 英文别名: 2-(3-Phenyl-2-propenylidene)hydrazinecarboximidamide；2-[(E)-[(E)-3-phenylprop-2-enylidene]amino]guanidine
• CAS: 5382-85-4
• 化学式: C₁₀H₁₂N₄
• 分子量: 188.232
• InChiKey: ZIXIIJQSFSAZOL-ZAUJTXRMSA-N

物化性质

• 沸点：
  333.4±35.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.8
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  肼甲酰亚胺酰胺一氯化氢 、 肉桂醛 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以34%的产率得到(E)-2-((E)-3-phenylallylidene)hydrazine-1-carboximidamide
  参考文献：
  名称：

  不对称和单体罗布定类似物的革兰氏阳性和革兰氏阴性抗生素活性

  摘要：

  罗非替丁的去对称化（1：N '，2-二（（E）-4-氯苄叉）肼-1-羧酰亚胺肼）和亚胺烷基取代基的引入具有良好的抗生素活性。值得注意的是，两种类似物对耐万古霉素的肠球菌（VRE）的效力有所提高，其中一种的MIC为0.5μgmL -1。发现有五个类似物比铅1具有更强的效价。吲哚部分的引入导致针对甲氧西林抗性金黄色葡萄球菌（MRSA）的活性最强的robenidine类似物，MIC为1.0μgmL -1。亚胺C = NH等位基因（C = O / C = S）不活跃。单体类似物为16–64μgmL-1对MRSA和VRE有效。缺少末端酰肼NH部分的类似物在64μgmL -1下显示适度的革兰氏阴性活性。研究表明，在16–64μgmL -1下， 4-叔丁基类似物对革兰氏阳性和阴性菌株均具有活性。通常，除伴随引入亚胺C-烷基外，对芳香族基团的其他修饰耐受性差。这些类似物对MRSA和VRE的活性范围为8μgmL

  DOI：

  10.1002/cmdc.201800463

文献信息

• ALKYLIDENE AMINOGUANIDINE AND SALT THEREOF, MODIFYING COMPOSITION, MODIFIED RUBBER FOR TIRE, RUBBER COMPOSITION FOR TIRE, AND TIRE
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：US20170129850A1

  公开（公告）日：2017-05-11

  Provided is a compound represented by formula (1): wherein X is an acid to form a salt with a guanidine site; and R 1 and R 2 are each independently any selected from the group consisting of a hydrogen atom, a C 1-18 alkyl group, a cycloalkyl group, an aryl group, an alkylaryl group, and an alkenyl group, each of the groups optionally having one or more substituents each containing a sulfur atom, a nitrogen atom, or an oxygen atom.

  提供的化合物由以下式表示： 其中X是一种酸，用于与胍位形成盐；而R1和R2分别独立地选自以下组合：氢原子、C1-18烷基、环烷基、芳基、烷基芳基和烯基，每种基团可选地具有一个或多个含有硫原子、氮原子或氧原子的取代基。
• ALKYLIDENE AMINOGANIDINE AND SALT THEREOF, MODIFIER COMPOSITION, MODIFIED RUBBER FOR TIRE, RUBBER COMPOSITION FOR TIRE, AND TIRE
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP3156394A1

  公开（公告）日：2017-04-19

  Provided is a compound represented by formula (1): wherein X is an acid to form a salt with a guanidine site; and R1 and R2 are each independently any selected from the group consisting of a hydrogen atom, a C1-18 alkyl group, a cycloalkyl group, an aryl group, an alkylaryl group, and an alkenyl group, each of the groups optionally having one or more substituents each containing a sulfur atom, a nitrogen atom, or an oxygen atom.

  本发明提供了一种由式（1）表示的化合物： 其中 X 是一种酸，可与胍基点形成盐；R1 和 R2 各自独立地任意选自氢原子、C1-18 烷基、环烷基、芳基、烷芳基和烯基组成的组，每个基团可选择具有一个或多个取代基，每个取代基含有一个硫原子、一个氮原子或一个氧原子。
• Alkylidene aminoguanidine and salt thereof, modifying composition, modified rubber for tire, rubber composition for tire, and tire
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：US10173973B2

  公开（公告）日：2019-01-08

  Provided is a compound represented by formula (1): wherein X is an acid to form a salt with a guanidine site; and R1 and R2 are each independently any selected from the group consisting of a hydrogen atom, a C1-18 alkyl group, a cycloalkyl group, an aryl group, an alkylaryl group, and an alkenyl group, each of the groups optionally having one or more substituents each containing a sulfur atom, a nitrogen atom, or an oxygen atom.

  本发明提供了一种由式（1）表示的化合物： 其中 X 是一种酸，可与胍基点形成盐；R1 和 R2 各自独立地任意选自氢原子、C1-18 烷基、环烷基、芳基、烷芳基和烯基组成的组，每个基团可选择具有一个或多个取代基，每个取代基含有一个硫原子、一个氮原子或一个氧原子。
• METHODS FOR TREATING PROTOZOAN INFECTIONS
  申请人：Neoculi Pty Ltd

  公开号：EP3188722A1

  公开（公告）日：2017-07-12
• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.