1-methyl-3-(p-tolylsulfonylethyl)thymine | 1112323-45-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methyl-3-(p-tolylsulfonylethyl)thymine
• 英文别名: 1,5-Dimethyl-3-[2-(4-methylphenyl)sulfonylethyl]pyrimidine-2,4-dione
• CAS: 1112323-45-1
• 化学式: C₁₅H₁₈N₂O₄S
• 分子量: 322.385
• InChiKey: ULOIKYDTWODCGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-甲基脲嘧啶 、 对甲苯基乙烯基砜 在 potassium carbonate 作用下， 以 水 为溶剂， 反应 1.0h， 以75%的产率得到1-methyl-3-(p-tolylsulfonylethyl)thymine
  参考文献：
  名称：

  EP2189503

  摘要：

  公开号：

文献信息

• NOVEL NUCLEIC ACID DERIVATIVE INTO WHICH GIVEN COMPOUND HAS BEEN INTRODUCED AND METHOD FOR PRODUCING THE SAME
  申请人：Biodynamics Laboratory, INC.

  公开号：EP2189503A1

  公开（公告）日：2010-05-26

  The objective of the invention is to provide nucleic acid derivatives with designated compounds introduced specifically into the base of nucleic acids. A DNA or RNA, or a nucleic acid molecular weight marker, wherein a designated compound (R), which is selected from any one of dyes, fluorescent dyes, RI labeled substances, and compounds capable of linking specifically to other compounds, is introduced at the N-3 position of a thymine base or uracil base in which (R') at Position 1 is other than hydrogen atom.

  本发明的目的是提供核酸衍生物，在核酸碱基中特异性地引入指定化合物。一种 DNA 或 RNA，或一种核酸分子量标记物，其中指定化合物（R）选自染料、荧光染料、RI 标记物质和能与其他化合物特异性连接的化合物中的任一种，被引入到胸腺嘧啶碱基或尿嘧啶碱基的 N-3 位，其中位 1 上的（R'）不是氢原子。
• NUCLEIC ACID DERIVATIVES AND METHODS OF USE
  申请人：Kato Toshiyuki

  公开号：US20090090628A1

  公开（公告）日：2009-04-09

  The objective of the invention is to provide nucleic acid derivatives with designated compounds introduced specifically into the base of nucleic acids. A DNA or RNA, or a nucleic acid molecular weight marker, wherein a designated compound (R), which is selected from any one of dyes, fluorescent dyes, RI labeled substances, and compounds capable of linking specifically to other compounds, is introduced at the N−3 position of a thymine base or uracil base in which (R′) at Position 1 is other than hydrogen atom.