1-(4-methylphenylsulfonyl)-4-[1-(4-methylphenylsulfonyl)-4,5-dihydro-1H-pyrrol-2-yl]-3-(3-nitrophenyl)imidazolidin-2-one | 1225465-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-methylphenylsulfonyl)-4-[1-(4-methylphenylsulfonyl)-4,5-dihydro-1H-pyrrol-2-yl]-3-(3-nitrophenyl)imidazolidin-2-one
• 英文别名: 1-(4-Methylphenyl)sulfonyl-4-[1-(4-methylphenyl)sulfonyl-2,3-dihydropyrrol-5-yl]-3-(3-nitrophenyl)imidazolidin-2-one
• CAS: 1225465-87-1
• 化学式: C₂₇H₂₆N₄O₇S₂
• 分子量: 582.658
• InChiKey: JTHSBPXAFUVLLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  158
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-{4-[1-(4-methylphenylsulfonyl)aziridin-2-yl]but-3-ynyl}-4-methylphenylsulfonamide 、 3-硝基苯异氢酸酯 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 0.02h， 以93%的产率得到1-(4-methylphenylsulfonyl)-4-[1-(4-methylphenylsulfonyl)-4,5-dihydro-1H-pyrrol-2-yl]-3-(3-nitrophenyl)imidazolidin-2-one
  参考文献：
  名称：

  Construction of Linked Nitrogen Heterocycles by Palladium(0)-Catalyzed Intramolecular Domino Cyclization of 2-Alkynylaziridines Bearing a 2-Aminoethyl Group via Ring Expansion with Isocyanate

  摘要：

  A novel palladium(0)-catalyzed domino cyclization of 2-alkynylaziridines with isocyanates through ring expansion is described. Treatment of N-protected 2-(4-aminobut-1-ynyl)aziridine derivatives With a catalytic amount of Pd(PPh(3))(4) and aryl isocyanates in THF at room temperature affords 4-(4,5-dihydropyrrol-2-yl)imidazolidin-2-one derivatives in good yields. Interestingly, bis-adducts were selectively obtained by use of excess isocyanate (5 equiv) at lower reaction temperature.

  DOI：

  10.1021/jo100462w

文献信息

• Construction of Linked Nitrogen Heterocycles by Palladium(0)-Catalyzed Intramolecular Domino Cyclization of 2-Alkynylaziridines Bearing a 2-Aminoethyl Group via Ring Expansion with Isocyanate
  作者：Akinori Okano、Shinya Oishi、Tetsuaki Tanaka、Nobutaka Fujii、Hiroaki Ohno

  DOI：10.1021/jo100462w

  日期：2010.5.21

  A novel palladium(0)-catalyzed domino cyclization of 2-alkynylaziridines with isocyanates through ring expansion is described. Treatment of N-protected 2-(4-aminobut-1-ynyl)aziridine derivatives With a catalytic amount of Pd(PPh(3))(4) and aryl isocyanates in THF at room temperature affords 4-(4,5-dihydropyrrol-2-yl)imidazolidin-2-one derivatives in good yields. Interestingly, bis-adducts were selectively obtained by use of excess isocyanate (5 equiv) at lower reaction temperature.