3-Fluoro-4,8-dimethyl-4'-(iodomethyl)-4',5'-dihydropsoralen | 273410-08-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-Fluoro-4,8-dimethyl-4'-(iodomethyl)-4',5'-dihydropsoralen
• 英文别名: 6-Fluoro-3-(iodomethyl)-5,9-dimethyl-2,3-dihydrofuro[3,2-g]chromen-7-one
• CAS: 273410-08-5
• 化学式: C₁₄H₁₂FIO₃
• 分子量: 374.15
• InChiKey: SQGLLINIAVUPGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP1115707A1

  公开（公告）日：2001-07-18
• 4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF
  申请人：BUCKMAN LABORATORIES INTERNATIONAL, INC.

  公开号：EP1144417A1

  公开（公告）日：2001-10-17
• US6177424B1
  申请人：——

  公开号：US6177424B1

  公开（公告）日：2001-01-23
• [EN] 4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF<br/>[FR] DIHYDROPSORALENES-4', 5' SUBSTITUES EN POSITION 4 ET LEURS UTILISATIONS THERAPEUTIQUES
  申请人：BUCKMAN LABOR INC

  公开号：WO2000032603A1

  公开（公告）日：2000-06-08

  The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula (V). In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR?1R2, or (N+R1R2R3)X-, R1 and R2¿ are independently a C¿1?-C6 alkyl, or R?1 and R2¿ together with the nitrogen form a 5-8 member heterocyclic ring, or when T is (N?+R1R2R3)X-, R1 and R2¿ together with the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring; R3 is hydroge, a C¿1?-C12 alkyl, or, when R?1 and R2¿ together with the nitrogen form a heterocyclic aromatic ring, R3 is a double bond within the heterocyclic aromatic ring; X is a halide. In another embodiment, the invention relates to processes for preparing 4'-substituted-4',5'-dihydropsoralen compounds described above. The compounds of the invention have beneficial pharmaceutical properties and can be used alone or in pharmaceutical compositions used to treat a proliferative skin disorder and to treat microbial infections in a mammal by administering to the mammal an effective amount of a compound of the invention and then irradiating the mammal with ultraviolet light.
• [EN] BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS<br/>[FR] DERIVES DE BENZAMIDE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE CYTOKINES
  申请人：ZENECA LTD

  公开号：WO2000018738A1

  公开（公告）日：2000-04-06

  The invention concerns amide derivatives of formula (I) wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R?1 and R2¿ is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R4 is a basic group such as amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, di-[(1-6C)alkyl]amino-(1-6C)alkyl, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, heteroaryl, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; and Q2 is a group such as heteroaryl, heteroaryloxy or heteroaryl-(1-6C)alkoxy which is optionally substituted; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.