thiophosphoric acid O-[7-(4-octyl-phenyl)-heptyl] ester | 849721-62-6

• 分子结构分类: 有机化合物
• 英文名称: thiophosphoric acid O-[7-(4-octyl-phenyl)-heptyl] ester
• 英文别名: Dihydroxy-[7-(4-octylphenyl)heptoxy]-sulfanylidene-lambda5-phosphane；dihydroxy-[7-(4-octylphenyl)heptoxy]-sulfanylidene-λ5-phosphane
• CAS: 849721-62-6
• 化学式: C₂₁H₃₇O₃PS
• 分子量: 400.563
• InChiKey: DOZOQIBQOOFRFP-UHFFFAOYSA-N

物化性质

• 沸点：
  519.7±53.0 °C(Predicted)
• 密度：
  1.057±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• LPA receptor agonists and antagonists and methods of use
  申请人：Miller D. Duane

  公开号：US20060009507A1

  公开（公告）日：2006-01-12

  The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

  本发明涉及公式（I）所示的化合物，以及包括这些化合物的制药组合物。还公开了使用这些化合物的方法，这些化合物具有作为LPA受体的激动剂或拮抗剂的活性；这些方法包括抑制LPA受体上的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗凋亡或在细胞、组织或器官中保持或恢复功能，培养细胞，保护器官或组织功能，以及治疗皮肤病症。
• LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE
  申请人：Miller Duane D.

  公开号：US20120135967A1

  公开（公告）日：2012-05-31

  Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

  本发明公开了按照公式(I)的化合物，以及包括这些化合物的制药组合物。还公开了使用这些化合物的方法，这些化合物具有作为LPA受体的激动剂或拮抗剂的活性。这些方法包括抑制LPA在LPA受体上的活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗凋亡或保护或恢复细胞、组织或器官的功能，培养细胞，保护器官或组织功能以及治疗皮肤病条件。
• EP1678096A4
  申请人：——

  公开号：EP1678096A4

  公开（公告）日：2007-04-18
• JP2007508324A
  申请人：——

  公开号：JP2007508324A

  公开（公告）日：2007-04-05
• US7217704B2
  申请人：——

  公开号：US7217704B2

  公开（公告）日：2007-05-15