N-(3,6-dibromo-pyrazin-2-yl)-N'-hydroxyformamidine | 959755-44-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(3,6-dibromo-pyrazin-2-yl)-N'-hydroxyformamidine
• 英文别名: N'-(3,6-dibromopyrazin-2-yl)-N-hydroxymethanimidamide
• CAS: 959755-44-3
• 化学式: C₅H₄Br₂N₄O
• 分子量: 295.921
• InChiKey: OAJCLHJEKKLVKM-UHFFFAOYSA-N

物化性质

• 沸点：
  379.3±52.0 °C(Predicted)
• 密度：
  2.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3,6-dibromo-pyrazin-2-yl)-N'-hydroxyformamidine 在 PPA 、 N,N-二异丙基乙胺 作用下， 以 异丙醇 为溶剂， 反应 10.75h， 生成 (5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine
  参考文献：
  名称：

  WO2007/138072

  摘要：

  公开号：
• 作为产物：
  描述：

  N'-(3,6-dibromo-pyrazin-2-yl)-N,N-dimethylformamidine 在 盐酸羟胺 作用下， 以 甲醇 为溶剂， 反应 16.0h， 生成 N-(3,6-dibromo-pyrazin-2-yl)-N'-hydroxyformamidine
  参考文献：
  名称：

  FUSED PYRAZINE COMPOUNDS AS THEIR SALTS, USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

  摘要：

  根据公式I，一种[1.2.4]三氮唑[1,5-a]吡嗪化合物的新型盐：这些盐可以制备成药物组合物，并可用于预防和治疗哺乳动物，包括人类的各种疾病条件，例如炎症等。

  公开号：

  US20110118269A1

文献信息

• FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Andrews Martin James Inglis

  公开号：US20090286798A1

  公开（公告）日：2009-11-19

  Novel[1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  揭示了具有以下表示的公式的新型[1.2.4]三唑并咪唑[1,2-a]吡嗪化合物：这些化合物可以制备为药物组合物，并可用于哺乳动物包括人类的预防和治疗多种疾病，包括但不限于疼痛、炎症等。
• Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
  申请人：Andrews Martin James Inglis

  公开号：US20090012078A1

  公开（公告）日：2009-01-08

  Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

  披萨嗪类新型化合物的公式如下所示：其中，这些化合物可以制备为药物组合物，用于预防和治疗哺乳动物包括人类的各种病症，例如炎症、类风湿关节炎等。
• Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases
  申请人：Andrews Inglis Martin James

  公开号：US20080090818A1

  公开（公告）日：2008-04-17

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  本发明揭示了一种Novel [1.2.4]triazolo[1,5-a]pyrazine化合物，其化学式如下：这些化合物可以制备成药物组成物，并可用于哺乳动物包括人类的预防和治疗多种疾病，例如，但不限于疼痛、炎症等。
• TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Andrews Martin James Inglis

  公开号：US20110178067A1

  公开（公告）日：2011-07-21

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  揭示了一种Novel [1.2.4]三唑并[1,5-a]吡嗪化合物，其化学式如下：这些化合物可以制备为药物组合物，并可用于哺乳动物，包括人类的预防和治疗多种病症，例如疼痛、炎症等，但不限于此。
• Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
  申请人：Galapagos NV

  公开号：US07915256B2

  公开（公告）日：2011-03-29

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  公开了一种Novel [1.2.4]三唑并[1,5-a]吡嗪化合物，其化学式如下所示：这些化合物可以制备成药物组合物，并可用于哺乳动物（包括人类）的预防和治疗多种疾病，例如疼痛、炎症等等。