4-[[3-[5-[(5-Iodo-2-methylphenyl)methyl]thiophen-2-yl]phenyl]methyl]morpholine | 1373555-98-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[3-[5-[(5-Iodo-2-methylphenyl)methyl]thiophen-2-yl]phenyl]methyl]morpholine
• CAS: 1373555-98-6
• 化学式: C₂₃H₂₄INOS
• 分子量: 489.42
• InChiKey: JHZDMQDTIHPPQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[[3-[5-[(5-Iodo-2-methylphenyl)methyl]thiophen-2-yl]phenyl]methyl]morpholine 在 cerium(III) chloride heptahydrate 、 异丙基氯化镁 、 lithium chloride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 3.33h， 生成 (3aS,5S,6R,6aS)-5-[hydroxy-[4-methyl-3-[[5-[3-(morpholin-4-ylmethyl)phenyl]thiophen-2-yl]methyl]phenyl]methyl]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol
  参考文献：
  名称：

  C-ARYLGLUCOSIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

  摘要：

  公开号：

  EP2634184B1

文献信息

• C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：Luo Huibing

  公开号：US20130225514A1

  公开（公告）日：2013-08-29

  The present invention relates to a C-aryl glucoside derivative of Formula (I) below, a preparation method therefor and a use thereof, wherein X, R 1 , R 2 , R 3 , R 4 , m and n are as defined in specification. The derivative of the present invention is a sodium-glucose co-transporter 2 (SGLT-2) inhibitor associated with glucose reabsorption of bowel or kidney, and has a good urine glucose excreting effect, thus being useful as a therapeutic agent for treating diabetes and related diseases.

  本发明涉及以下式（I）的C-芳基葡萄糖苷衍生物，其制备方法和用途，其中X，R1，R2，R3，R4，m和n如规范中所定义。本发明的衍生物是一种钠-葡萄糖共转运体2（SGLT-2）抑制剂，与肠或肾的葡萄糖重吸收有关，并具有良好的尿糖排泄作用，因此可用作治疗糖尿病及相关疾病的治疗剂。
• US8871726B2
  申请人：——

  公开号：US8871726B2

  公开（公告）日：2014-10-28
• [EN] C-ARYLGLUCOSIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF<br/>[FR] DÉRIVÉ DE C-ARYLGLUCOSIDE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
  申请人：SHANGHAI ALLIST PHARMACEUTICALS INC

  公开号：WO2012055169A1

  公开（公告）日：2012-05-03

  The present invention relates to a C-arylglucoside derivative of Formula (I) below, a preparation method therefor and a use thereof, wherein X, R1, R2, R3, R4, m and n are as defined in specification. The derivative of the present invention is a sodium-glucose co-transporters 2 (SGLT-2) inhibitor associated with glucose reabsorption of bowel or kidney, and has a good urine glucose excreting effect, thus being useful as a therapeutic agent for treating diabetes and related diseases.