2-(6-aminopurin-9-yl)-N-(2-hydroxyethyl)-N-methylacetamide | 202915-76-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-(6-aminopurin-9-yl)-N-(2-hydroxyethyl)-N-methylacetamide
• CAS: 202915-76-2
• 化学式: C₁₀H₁₄N₆O₂
• 分子量: 250.26
• InChiKey: NTFZVRWWCOECQG-UHFFFAOYSA-N

物化性质

• 沸点：
  557.6±60.0 °C(Predicted)
• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.14
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  110.16
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-(6-aminopurin-9-yl)-N-(2-hydroxyethyl)-N-methylacetamide 生成 [2-[[2-(6-Aminopurin-9-yl)acetyl]-methylamino]ethoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
  参考文献：
  名称：

  Acyclic nucleoside triphosphate analogs as terminators in biocatalytic DNA replication

  摘要：

  The acyclic nucleoside triphosphates 1 and 2 were prepared and tested as substrates for several DNA replicating enzymes; AmpliTaq(R) FS and Taquenase(R) accepted these compounds as substrates leading to chain termination. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10135-4
• 作为产物：
  描述：

  在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(6-aminopurin-9-yl)-N-(2-hydroxyethyl)-N-methylacetamide
  参考文献：
  名称：

  Acyclic nucleoside triphosphate analogs as terminators in biocatalytic DNA replication

  摘要：

  The acyclic nucleoside triphosphates 1 and 2 were prepared and tested as substrates for several DNA replicating enzymes; AmpliTaq(R) FS and Taquenase(R) accepted these compounds as substrates leading to chain termination. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10135-4