2-(2-((Z)-2-(naphthalen-2-yl)vinyl)-5-nitro-1H-imidazol-1-yl)ethanol | 1621879-65-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2-((Z)-2-(naphthalen-2-yl)vinyl)-5-nitro-1H-imidazol-1-yl)ethanol
• CAS: 1621879-65-9
• 化学式: C₁₇H₁₅N₃O₃
• 分子量: 309.324
• InChiKey: WVEXGDNFHFPFTO-VURMDHGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.11
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  81.19
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(2-((Z)-2-(naphthalen-2-yl)vinyl)-5-nitro-1H-imidazol-1-yl)ethanol 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 2-(2-((Z)-2-(naphthalen-2-yl)vinyl)-5-nitro-1H-imidazol-1-yl)ethyl 1H-indole-3-carboxylate
  参考文献：
  名称：

  Discovery and molecular modeling of novel 1-indolyl acetate – 5-Nitroimidazole targeting tubulin polymerization as antiproliferative agents

  摘要：

  A series of 18 novel 1-indolyl acetate-5-nitroimidazole 3a-3r were designed, synthesized, and evaluated for their in vitro biological activities as potential tubulin polymerization inhibitors. Among these compounds, 3p displayed strong antitumor activity with IC50 of 2.00, 1.05, 0.87 mu M against A549, Hela and U251 respectively, and also showed the most potent PLK1 inhibitory activity with IC50 of 2.4 mu M. Molecular docking studies within the colchicine binding site of tubulin were in good agreement with the tubulin polymerization inhibitory data and confirmed the importance of the configuration of the synthesized 1-indolyl acetate-5-nitroimidazolefor potential tubulin polymerization inhibitors. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.07.082
• 作为产物：
  描述：

  2-萘甲醛 、 甲硝唑 在 sodium methylate 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 反应 4.0h， 以71.4%的产率得到2-(2-((Z)-2-(naphthalen-2-yl)vinyl)-5-nitro-1H-imidazol-1-yl)ethanol
  参考文献：
  名称：

  Discovery and molecular modeling of novel 1-indolyl acetate – 5-Nitroimidazole targeting tubulin polymerization as antiproliferative agents

  摘要：

  A series of 18 novel 1-indolyl acetate-5-nitroimidazole 3a-3r were designed, synthesized, and evaluated for their in vitro biological activities as potential tubulin polymerization inhibitors. Among these compounds, 3p displayed strong antitumor activity with IC50 of 2.00, 1.05, 0.87 mu M against A549, Hela and U251 respectively, and also showed the most potent PLK1 inhibitory activity with IC50 of 2.4 mu M. Molecular docking studies within the colchicine binding site of tubulin were in good agreement with the tubulin polymerization inhibitory data and confirmed the importance of the configuration of the synthesized 1-indolyl acetate-5-nitroimidazolefor potential tubulin polymerization inhibitors. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.07.082