N-[(4-methoxyphenyl)methyl]-4-nitro-N-propylbenzenesulfonamide | 1027628-05-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4-methoxyphenyl)methyl]-4-nitro-N-propylbenzenesulfonamide
• CAS: 1027628-05-2
• 化学式: C₁₇H₂₀N₂O₅S
• 分子量: 364.422
• InChiKey: PNKCIUCRNWOZPE-UHFFFAOYSA-N

物化性质

• 沸点：
  531.4±60.0 °C(Predicted)
• 密度：
  1.280±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[(4-methoxyphenyl)methyl]-4-nitro-N-propylbenzenesulfonamide 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以95%的产率得到N-(4-甲氧基苄基)丙基胺
  参考文献：
  名称：

  Application of Odorless Thiols for the Cleavage of 2‐ and 4‐Nitrobenzenesulfonamides

  摘要：

  Several odorless or faint-smelling thiols were tested to cleave 2- and 4-nitrobenzenesulfonyl groups, which are widely utilized for selective protection and activation of amines. p-Mercaptobenzoic acid (7) was found to be the most useful thiol for cleaving the o- and p-nosyl groups in terms of ease of separation of the product from the workup residue, reaction temperature, and reaction time.

  DOI：

  10.1080/00397910701866098

文献信息

• Application of Odorless Thiols for the Cleavage of 2‐ and 4‐Nitrobenzenesulfonamides
  作者：Manabu Matoba、Tetsuya Kajimoto、Manabu Node

  DOI：10.1080/00397910701866098

  日期：2008.3.28

  Several odorless or faint-smelling thiols were tested to cleave 2- and 4-nitrobenzenesulfonyl groups, which are widely utilized for selective protection and activation of amines. p-Mercaptobenzoic acid (7) was found to be the most useful thiol for cleaving the o- and p-nosyl groups in terms of ease of separation of the product from the workup residue, reaction temperature, and reaction time.