2-[(E)-2-吡啶-2-基乙烯基]苯酚 | 19087-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[(E)-2-吡啶-2-基乙烯基]苯酚
• 英文名称: (E)-2-[2-(pyridin-2-yl)ethenyl]phenol
• 英文别名: (E)-2-(2-pyridin-2-yl-vinyl)-phenol；(E)-2-[2-(pyridin-2-yl)vinyl]phenol；(E)-α-azastilbenol-2'；E-2-o-hydroxystyrylpyridine；2-(2-pyridin-2-yl-vinyl)-phenol；2-(trans-2-[2]Pyridyl-vinyl)-phenol；2-[(E)-2-pyridin-2-ylvinyl]phenol；2-[(E)-2-pyridin-2-ylethenyl]phenol
• CAS: 19087-55-9；77377-06-1
• 化学式: C₁₃H₁₁NO
• mdl: MFCD00090266
• 分子量: 197.236
• InChiKey: QXGALKDRRMKWHN-CMDGGOBGSA-N

物化性质

• 熔点：
  143-144 °C
• 沸点：
  352.4±11.0 °C(Predicted)
• 密度：
  1.200±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(E)-2-吡啶-2-基乙烯基]苯酚 在 碘苯二乙酸 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以79%的产率得到2-(benzofuran-2-yl)pyridine
  参考文献：
  名称：

  Hypervalent Iodine Mediated Oxidative Cyclization of o-Hydroxystilbenes into Benzo- and Naphthofurans

  摘要：

  A new and convenient metal-free cyclization of ortho-hydroxystilbenes into 2-arylbenzofurans and 2-arylnaphthofurans mediated by hypervalent iodine reagents is described. The cyclization products are isolated in good to excellent yields using stoichiometric (diacetoxyiodo)benzene in acetonitrile.

  DOI：

  10.1055/s-0031-1290588
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 水 、 溶剂黄146 作用下， 生成 2-[(E)-2-吡啶-2-基乙烯基]苯酚
  参考文献：
  名称：

  138. Cinnolines。第七部分 关于Widman-Stoermer反应的进一步观察

  摘要：

  DOI：

  10.1039/jr9460000673

文献信息

• Lewis-Acid-Catalyzed Benzylic Reactions of 2-Methylazaarenes with Aldehydes
  作者：Dan Mao、Gang Hong、Shengying Wu、Xin Liu、Jianjun Yu、Limin Wang

  DOI：10.1002/ejoc.201400073

  日期：2014.5

  Lewis-acid-catalyzed benzylic reactions of 2-methylazaarenes with aldehydes have been investigated. Series of azaarene derivatives were afforded by this reaction. 2-(Pyridin-2-yl)ethanols with common substituents were formed through the LiNTf2-promoted aldol reaction for the first time. 2-Alkenylpyridines, exclusively in the form of the E isomers, were synthesized in the presence of LiNTf2 cooperated

  已经研究了路易斯酸催化的 2-甲基氮杂芳烃与醛的苄基反应。该反应得到一系列氮杂芳烃衍生物。首次通过LiNTf2促进的羟醛反应形成了具有常见取代基的2-(Pyridin-2-yl)乙醇。在 LiNTf2 与 H2NTf 协同作用下，合成了仅以 E 异构体形式存在的 2-烯基吡啶。在La(Pfb)3催化下，2-甲基喹啉与醛类在空气中反应，以高收率得到2-烯基喹啉。
• Utilities of olefin derivatives
  申请人：——

  公开号：US20040242615A1

  公开（公告）日：2004-12-02

  Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): 1 in which Ar 1 and Ar 2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ 2 -, —CY 2 ═CZ 2 -, —CY 2 Y 3 —CHZ 2 -, —S—, —O—, or the like; Y 1 , Y 2 , Y 3 , Z 1 and Z 2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z 1 and Z 2 may be independently a linker group that may combine with Ar 2 and Ar 1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them; are disclosed.

  提供了一种增强apoAI表达活性的化合物。 公式 (I) 的化合物：1 其中Ar1和Ar2独立的是苯基、萘基或单环或双环芳族杂环族，可被选择性地取代； —X—是—N═CZ2-, —CY2═CZ2-, —CY2Y3—CHZ2-, —S—, —O—或类似物； Y1、Y2、Y3、Z1和Z2独立的是氢、卤素、低级烷基、苯基或类似物； Z1和Z2可以独立的是可以与Ar2和Ar1形成缩合环的连接基团； m是0或1，n是0到2； 它们的前药、药用盐或溶剂化物被公开。
• Pyridine compounds which have useful pharmaceutical activity
  申请人：Boehringer Mannheim GmbH

  公开号：US05399575A1

  公开（公告）日：1995-03-21

  Compounds of the formula I ##STR1## in which A signifies an alkylene radical with 1 to 3 carbon atoms or a group --CH.dbd.CH--, B an oxygen atom or a valency bond, m a whole number from 0 to 5, n the number 0 or 1, X a valency bond, an oxygen atom or a sulphur atom, Y a valency bond or a phenylene radical substituted, if desired, one or more times by C.sub.1 - to C.sub.6 -alkyl, C.sub.1 - to C.sub.6 -alkoxy, halogen, hydroxyl or aminocarbonyl, Z hydrogen, halogen, C.sub.1 - to C.sub.6 -alkyl or cyano and R a group CN, COOH, COOC.sub.1 - to C.sub.6 -alkyl, CONH-tetrazolyl, CON(OH)(C.sub.1 -C.sub.6 -alkyl) or 5-(1H)-tetrazolyl, as well as, for the case that Y represents a phenylene radical, also hydrogen, with the exception of the compound 4-[2-(4)-pyridinovinyl]-carboxymethoxybenzene, their physiologically compatible salts and processes for their preparation, as well as medicaments containing these compounds for the treatment of allergic diseases.

  式I的化合物##STR1##其中A表示1至3个碳原子的烷基基团或一个基团--CH.dbd.CH--, B表示氧原子或一个价键，m是0至5的整数，n是0或1，X表示一个价键，一个氧原子或一个硫原子，Y表示一个价键或一个苯基基团，如果需要，可以被C.sub.1 -至C.sub.6 -烷基，C.sub.1 -至C.sub.6 -烷氧基，卤素，羟基或氨基甲酰取代一次或多次，Z表示氢，卤素，C.sub.1 -至C.sub.6 -烷基或氰基，R表示一个基团CN，COOH，COOC.sub.1 -至C.sub.6 -烷基，CONH-四唑基，CON(OH)(C.sub.1 -C.sub.6 -烷基)或5-(1H)-四唑基，以及，对于Y表示苯基基团的情况，还有氢，除了化合物4-[2-(4)-吡啶乙烯基]-羧甲氧基苯，它们的生理相容性盐以及其制备方法，以及含有这些化合物用于治疗过敏疾病的药物。
• Anti-Angiogenic Compounds
  申请人：UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN

  公开号：US20160326122A1

  公开（公告）日：2016-11-10

  Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age-related macular degeneration, diabetic retinopathy or cancer.

  描述了一些化合物和组合物，特别适用于治疗与血管生成相关的疾病或疾病，如眼部新血管生成、老年性黄斑变性、糖尿病性视网膜病变或癌症。
• [EN] ANTI-ANGIOGENIC COMPOUNDS<br/>[FR] COMPOSÉS ANTIANGIOGÉNIQUES
  申请人：UNIV DUBLIN

  公开号：WO2015107122A1

  公开（公告）日：2015-07-23

  Compounds of the formula A-X-Y-B and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age- related macular degeneration, diabetic retinopathy or cancer, wherein A is a six membered heteroaryl ring containing 2 nitrogen atoms which is optionally substituted with R1; R1 is H, CI-6 alkyl, CN, CONR2R3; R2 and R3 which may be the same or different and selected from H, CI-6 alkyl or R2 and R3 form a ring; the group X-Y is an alkyne or alkene, in the case wherein X-Y is an alkene the double bond may be cis or trans and optionally substituted with R1 B is an aryl; or five or six membered heteroaryl ring containing 1 to 3 heteroatoms, both of which may optionally substituted with one or more R4; R4 is R1 or OR5; R5 is H, COR6 or R6; and R6 is CI-6 alkyl and salts thereof.

  描述了化合物A-X-Y-B的结构式和组成物，这些化合物特别适用于治疗与血管生成相关的疾病或疾病，如眼部新血管生成、年龄相关性黄斑变性、糖尿病性视网膜病变或癌症，其中A是一个含有2个氮原子的六元杂环芳基环，可选择地取代为R1；R1为H、CI-6烷基、CN、CONR2R3；R2和R3可以相同也可以不同，选择自H、CI-6烷基或R2和R3形成环；X-Y是炔烃或烯烃，如果X-Y是烯烃，则双键可以为顺式或反式，并可选择地取代为R1；B是芳基；或含有1至3个杂原子的五元或六元杂环芳基环，两者均可选择地取代为一个或多个R4；R4为R1或OR5；R5为H、COR6或R6；R6为CI-6烷基及其盐。

表征谱图