4-(2-Phenylsulfanylethoxy)-biphenyl | 361485-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-Phenylsulfanylethoxy)-biphenyl
• 英文别名: 1-phenyl-4-(2-phenylsulfanylethoxy)benzene
• CAS: 361485-23-6
• 化学式: C₂₀H₁₈OS
• 分子量: 306.428
• InChiKey: LXKZRVXUYPFFHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-苯硫基乙醇 、 2-([1,1-联苯]-2-基)乙酸 在 ethyl acetate heptane 作用下， 以furnished 27.9 mg (91%) of the desired product as a solid (LC-MS: 89% UV-purity and 87% ELSD-purity)的产率得到
  参考文献：
  名称：

  Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form

  摘要：

  提供至少一种固态试剂的剂型，用于传统有机和无机合成，平行合成以及组合化学中的分裂和混合合成，该剂型为压缩片，每片含有相同预定量的至少一种试剂，嵌入在聚合物基质中，该基质包含不溶于预定合成溶剂的聚合物珠子，这些压缩片能够在所述溶剂中分解，释放至少一种试剂，并将基质分散为聚合物珠子。剂型中的聚合物珠子和试剂可以通过过滤轻松地从形成的可溶性产物中分离出来。在生产该剂型的方法中，用无极有机溶剂预处理后，将一种或多种聚合物珠子与试剂混合，并压缩成片。

  公开号：

  US20030138376A1

文献信息

• DOSING FORM FOR REAGENTS, USE OF SAID DOSING FORM IN ORGANIC CHEMICAL SYNTHESIS AND PRODUCTION OF SAID DOSING FORM
  申请人：H. Lundbeck A/S

  公开号：EP1268051A2

  公开（公告）日：2003-01-02
• [EN] DOSING FORM FOR REAGENTS, USE OF SAID DOSING FORM IN ORGANIC CHEMICAL SYNTHESIS AND PRODUCTION OF SAID DOSING FORM<br/>[FR] FORME DOSE POUR REACTIFS, UTILISATION DE CETTE FORME EN SYNTHESE ORGANIQUE ET PRODUCTION DE CETTE FORME DOSE
  申请人：LUNDBECK & CO AS H

  公开号：WO2001068599A2

  公开（公告）日：2001-09-20

  A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the same predetermined amount of said at least one reagent embedded in a polymer matrix comprising beads of a polymer insoluble in the solvents for the intended synthesis, which tablets are capable of disintegrating in said solvent for release of the at least one reagent and disperse the matrix as polymer beads into the solvent. The polymer beads forming the matrix and the reagents of the dosing form can easily be removed by filtration in order to separate these from a formed soluble product. In a method for producing the dosing form, beads of one or more polymers are mixed with the reagents and compressed into tablets after pre-treatment with an aprotic organic solvent.