(5R,6S,7S,8S,9R,10S,E)-11-(tert-butyldimethylsilyloxy)-9-methoxy-1-(4-methoxybenzyloxy)-4,6,8,10-tetramethylundec-3-ene-5,7-diol | 1187629-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5R,6S,7S,8S,9R,10S,E)-11-(tert-butyldimethylsilyloxy)-9-methoxy-1-(4-methoxybenzyloxy)-4,6,8,10-tetramethylundec-3-ene-5,7-diol
• CAS: 1187629-68-0
• 化学式: C₃₀H₅₄O₆Si
• 分子量: 538.841
• InChiKey: RUTOAAXFKBKHRO-DHGVGMNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.22
• 重原子数：
  37.0
• 可旋转键数：
  16.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  77.38
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (5R,6S,7S,8S,9R,10S,E)-11-(tert-butyldimethylsilyloxy)-9-methoxy-1-(4-methoxybenzyloxy)-4,6,8,10-tetramethylundec-3-ene-5,7-diol 、 2,2-二甲氧基丙烷 在 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 为溶剂， 以92%的产率得到tert-butyl((2S,3R,4R)-3-methoxy-4-((4R,5S,6R)-6-((E)-5-(4-methoxybenzyloxy)pent-2-en-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-2-methylpentyloxy)dimethylsilane
  参考文献：
  名称：

  Relative Stereochemical Determination and Synthesis of the C1−C17 Fragment of a New Natural Polyketide

  摘要：

  The challenging determination of the relative stereochemistry of a complex natural polyketide portion was achieved. After careful NMR analysis, a concise synthesis of a set of possible relative diastereomers (only 6 diastereomers out of the 32 initially envisioned) has been carried out using a common strategy based on enantioselective aldol reactions. With a high predictability, final NMR comparison established the relative stereochemistry of the C1-C17 fragment of this natural product.

  DOI：

  10.1021/jo9012833
• 作为产物：
  描述：

  (6S,7R,8S,9R,10S,E)-11-(tert-butyldimethylsilyloxy)-7-hydroxy-9-methoxy-1-(4-methoxybenzyloxy)-4,6,8,10-tetramethylundec-3-en-5-one 在 zinc(II) tetrahydroborate 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 以78%的产率得到(5R,6S,7S,8S,9R,10S,E)-11-(tert-butyldimethylsilyloxy)-9-methoxy-1-(4-methoxybenzyloxy)-4,6,8,10-tetramethylundec-3-ene-5,7-diol
  参考文献：
  名称：

  Relative Stereochemical Determination and Synthesis of the C1−C17 Fragment of a New Natural Polyketide

  摘要：

  The challenging determination of the relative stereochemistry of a complex natural polyketide portion was achieved. After careful NMR analysis, a concise synthesis of a set of possible relative diastereomers (only 6 diastereomers out of the 32 initially envisioned) has been carried out using a common strategy based on enantioselective aldol reactions. With a high predictability, final NMR comparison established the relative stereochemistry of the C1-C17 fragment of this natural product.

  DOI：

  10.1021/jo9012833