2-(4-methylphenoxy)-1,3-bis[(1S)-1-phenylethyl]-1,3,2lambda5-diazaphospholidine 2-oxide | 418770-81-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-methylphenoxy)-1,3-bis[(1S)-1-phenylethyl]-1,3,2lambda5-diazaphospholidine 2-oxide
• 英文别名: 2-(4-methylphenoxy)-1,3-bis[(1S)-1-phenylethyl]-1,3,2λ5-diazaphospholidine 2-oxide
• CAS: 418770-81-7
• 化学式: C₂₅H₂₉N₂O₂P
• 分子量: 420.491
• InChiKey: JPODVEGWLWYETA-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-methylphenoxy)-1,3-bis[(1S)-1-phenylethyl]-1,3,2lambda5-diazaphospholidine 2-oxide 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.25h， 以36%的产率得到4-Methyl-2-[2-oxo-1,3-bis-((S)-1-phenyl-ethyl)-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-phenol
  参考文献：
  名称：

  Synthesis of some new chiral cyclic o-hydroxylarylphosphonodiamides as ligands for asymmetric silylcyanation of aromatic aldehydes

  摘要：

  Some new chiral cyclic o-hydroxylarylphosphonodiamides were synthesized from (-)-alpha-phenylethylamine and found to be efficient ligands for the Ti(OPr-i)(4) catalyzed asymmetric trimethylsilylcyanation of aromatic aldehydes. Corresponding cyanohydrins were obtained in good chemical yield and enantiomeric excesses up to 90%. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2003.09.032
• 作为产物：
  描述：

  (S)-(-)- α-甲基苄胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 46.0h， 生成 2-(4-methylphenoxy)-1,3-bis[(1S)-1-phenylethyl]-1,3,2lambda5-diazaphospholidine 2-oxide
  参考文献：
  名称：

  Synthesis of some new chiral cyclic o-hydroxylarylphosphonodiamides as ligands for asymmetric silylcyanation of aromatic aldehydes

  摘要：

  Some new chiral cyclic o-hydroxylarylphosphonodiamides were synthesized from (-)-alpha-phenylethylamine and found to be efficient ligands for the Ti(OPr-i)(4) catalyzed asymmetric trimethylsilylcyanation of aromatic aldehydes. Corresponding cyanohydrins were obtained in good chemical yield and enantiomeric excesses up to 90%. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2003.09.032

文献信息

• Synthesis of some new chiral cyclic o-hydroxylarylphosphonodiamides as ligands for asymmetric silylcyanation of aromatic aldehydes
  作者：Zhuohong Yang、Zhenghong Zhou、Ke He、Lixin Wang、Guofeng Zhao、Qilin Zhou、Chuchi Tang

  DOI：10.1016/j.tetasy.2003.09.032

  日期：2003.12

  Some new chiral cyclic o-hydroxylarylphosphonodiamides were synthesized from (-)-alpha-phenylethylamine and found to be efficient ligands for the Ti(OPr-i)(4) catalyzed asymmetric trimethylsilylcyanation of aromatic aldehydes. Corresponding cyanohydrins were obtained in good chemical yield and enantiomeric excesses up to 90%. (C) 2003 Elsevier Ltd. All rights reserved.