8,8'-(((sulfonylbis(4,1-phenylene))bis(azaneylylidene))bis(methaneylylidene))bis(7-hydroxy-4-methyl-2H-chromen-2-one) | 1354440-96-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 8,8'-(((sulfonylbis(4,1-phenylene))bis(azaneylylidene))bis(methaneylylidene))bis(7-hydroxy-4-methyl-2H-chromen-2-one)
• CAS: 1354440-96-2
• 化学式: C₃₄H₂₄N₂O₈S
• 分子量: 620.639
• InChiKey: ITCIHVMEIAGSTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.26
• 重原子数：
  45.0
• 可旋转键数：
  6.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  159.74
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为产物：
  描述：

  7-羟基-4-甲基-2-氧代-2H-色烯-8-甲醛 、 氨苯砜 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以80%的产率得到8,8'-(((sulfonylbis(4,1-phenylene))bis(azaneylylidene))bis(methaneylylidene))bis(7-hydroxy-4-methyl-2H-chromen-2-one)
  参考文献：
  名称：

  DNA cleavage, antimicrobial, anti-inflammatory anthelmintic activities, and spectroscopic studies of Co(II), Ni(II), and Cu(II) complexes of biologically potential coumarin Schiff bases

  摘要：

  A series of Co(II), Ni(II) and Cu(II) complexes, [ML center dot 2H(2)O] of Schiff bases derived from 4, 4-diaminodiphenyl sulfone (dapsone) and 8-formyl-7-hydroxy-4-methylcoumarin/5-formyl-6-hydroxycoumarin have been synthesized. From analytical, spectral (IR, NMR, UV-Vis, ESR and FAB mass), and magnetic studies it has been concluded that the metal complexes possess octahedral geometry and are non-electrolytes. The redox behavior of the metal complexes is investigated by cyclic voltammetry. The Schiff bases and their metal complexes have been screened for antibacterial (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella, Salmonella, Streptococcus, Staphylococcus proteus) and antifungal activities (Fusarium, Candida, Rhizopus, Penicillium chrysogenum and Aspergillus niger) by the minimum inhibitory concentration method. The anthelmintic activity of the ligands and their metal complexes against earthworms was investigated. The DNA cleavage study was done by agarose gel electrophoresis. Anti-inflammatory activity studies showed the test compounds are comparable to the standard drug diclofenac sodium.

  DOI：

  10.1080/00958972.2011.621082