2-(4-chlorophenyl)-6-(thiophen-2-yl)-4-p-tolylpyridine | 1386425-48-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(4-chlorophenyl)-6-(thiophen-2-yl)-4-p-tolylpyridine
• 英文别名: 2-(4-chlorophenyl)-(thiophen-2-yl)-4-p-tolylpyridine；2-(4-Chlorophenyl)-4-(4-methylphenyl)-6-thiophen-2-ylpyridine
• CAS: 1386425-48-4
• 化学式: C₂₂H₁₆ClNS
• 分子量: 361.895
• InChiKey: QYFRESLMMMWCOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  potassium tetrachloroplatinate(II) 、 2-(4-chlorophenyl)-6-(thiophen-2-yl)-4-p-tolylpyridine 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 以65%的产率得到[PtCl₂(2-(4-chlorophenyl)-6-(thiophen-2-yl)-4-p-tolylpyridine)]
  参考文献：
  名称：

  DNA interaction and cytotoxic activities of square planar platinum(II) complexes with N, S-donor ligands

  摘要：

  The platinum(II) complexes with N, S-donor ligands have been synthesized and characterized by physicochemical methods viz, elemental, electronic, FT-IR, H-1 NMR and LC-MS spectra. The binding mode and potency of the complexes with HS DNA (Herring Sperm) have been examined by absorption titration and viscosity measurement studies. The results revealed that complexes bind to HS DNA via covalent mode with the intrinsic binding constant (K-b) in the range 1.37-7.76 x 10(5) M-1. Decrease in the relative viscosity of HS DNA also supports the covalent mode of binding. The DNA cleavage activity of synthesized complexes has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA; showing the unwinding of the negatively charged supercoiled DNA. Brine shrimp (Anemia Cysts) lethality bioassay technique has been applied for the determination of toxic property of synthesized complexes in terms of (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.02.053
• 作为产物：
  描述：

  对甲基苯甲醛 在 ammonium acetate 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 2-(4-chlorophenyl)-6-(thiophen-2-yl)-4-p-tolylpyridine
  参考文献：
  名称：

  DNA interaction and cytotoxic activities of square planar platinum(II) complexes with N, S-donor ligands

  摘要：

  The platinum(II) complexes with N, S-donor ligands have been synthesized and characterized by physicochemical methods viz, elemental, electronic, FT-IR, H-1 NMR and LC-MS spectra. The binding mode and potency of the complexes with HS DNA (Herring Sperm) have been examined by absorption titration and viscosity measurement studies. The results revealed that complexes bind to HS DNA via covalent mode with the intrinsic binding constant (K-b) in the range 1.37-7.76 x 10(5) M-1. Decrease in the relative viscosity of HS DNA also supports the covalent mode of binding. The DNA cleavage activity of synthesized complexes has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA; showing the unwinding of the negatively charged supercoiled DNA. Brine shrimp (Anemia Cysts) lethality bioassay technique has been applied for the determination of toxic property of synthesized complexes in terms of (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.02.053

文献信息

• Cytotoxic, DNA Interaction, SOD Mimic, and Antimicrobial Activities of Square Pyramidal Copper(II) Complexes
  作者：Mohan N. Patel、Chintan R. Patel、Hardik N. Joshi

  DOI：10.1002/zaac.201200052

  日期：2012.6

  Viscosity measurement and absorption titration were employed to determine the mode of binding of complexes with DNA. DNA cleavage activity was carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA. The complexes were screened for their SOD mimic activity in terms of IC50 value. The complexes were also checked for their cytotoxicity using brine shrimp assay method.

  合成了铜 (II) 与 NS 供体配体和环丙沙星的配合物。合成的配合物通过元素和热分析、电子、FT-IR 和 LC-MS 光谱等物理化学参数进行表征。根据 MIC (μM) 测试复合物对两种革兰氏 (+ve) 菌，即金黄色葡萄球菌、枯草芽孢杆菌和三种革兰 (-ve)，即粘质沙雷氏菌、铜绿假单胞菌、大肠杆菌的抗菌活性，结果为与母药相比。使用粘度测量和吸收滴定来确定复合物与 DNA 的结合模式。DNA切割活性通过凝胶电泳实验使用超螺旋形式的pUC19 DNA进行。根据 IC50 值筛选复合物的 SOD 模拟活性。