2-(bis((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-bromo-1H-benzo[de]isoquinoline-1,3(2H) dione | 1528606-70-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-(bis((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-bromo-1H-benzo[de]isoquinoline-1,3(2H) dione
• 英文别名: 2-[Bis[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl]amino]-6-bromobenzo[de]isoquinoline-1,3-dione；2-[bis[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl]amino]-6-bromobenzo[de]isoquinoline-1,3-dione
• CAS: 1528606-70-3
• 化学式: C₃₂H₂₃BrCl₂N₈O₂
• 分子量: 702.397
• InChiKey: SMNKVVLBLMHZOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  45
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(bis((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-bromo-1H-benzo[de]isoquinoline-1,3(2H) dione 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.0h， 以98%的产率得到2-(bis((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-bromo-1H-benzo[de]isoquinoline-1,3(2H)-dione dihydrochloride
  参考文献：
  名称：

  1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: Synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin

  摘要：

  A series of 1,2,3-triazole-derived naphthalimides as a novel type of potential antimicrobial agents were synthesized and characterized by IR, NMR and HRMS spectra. All the new compounds were screened for their antimicrobial activity against four Gram-positive bacteria, four Gram-negative bacteria and three fungi. Bioactive assay manifested that 3,4-dichlorobenzyl compound 9e and its corresponding hydrochloride 11e showed better anti-Escherichia coli activity than Norfloxacin and Chloromycin. Preliminary research revealed that compound 9e could effectively intercalate into calf thymus DNA to form compound 9e-DNA complex which might block DNA replication and thus exert antimicrobial activities. Human serum albumin could effectively store and carry compound 9e by electrostatic interaction. (C) 2013 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2013.11.013
• 作为产物：
  描述：

  N-amido-4-bromine-1,8-naphthalimide 在 copper(ll) sulfate pentahydrate 、 potassium carbonate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 51.0h， 生成 2-(bis((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-bromo-1H-benzo[de]isoquinoline-1,3(2H) dione
  参考文献：
  名称：

  1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: Synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin

  摘要：

  A series of 1,2,3-triazole-derived naphthalimides as a novel type of potential antimicrobial agents were synthesized and characterized by IR, NMR and HRMS spectra. All the new compounds were screened for their antimicrobial activity against four Gram-positive bacteria, four Gram-negative bacteria and three fungi. Bioactive assay manifested that 3,4-dichlorobenzyl compound 9e and its corresponding hydrochloride 11e showed better anti-Escherichia coli activity than Norfloxacin and Chloromycin. Preliminary research revealed that compound 9e could effectively intercalate into calf thymus DNA to form compound 9e-DNA complex which might block DNA replication and thus exert antimicrobial activities. Human serum albumin could effectively store and carry compound 9e by electrostatic interaction. (C) 2013 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2013.11.013

文献信息

• 1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: Synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin
  作者：Jing-Song Lv、Xin-Mei Peng、Baathulaa Kishore、Cheng-He Zhou

  DOI：10.1016/j.bmcl.2013.11.013

  日期：2014.1

  A series of 1,2,3-triazole-derived naphthalimides as a novel type of potential antimicrobial agents were synthesized and characterized by IR, NMR and HRMS spectra. All the new compounds were screened for their antimicrobial activity against four Gram-positive bacteria, four Gram-negative bacteria and three fungi. Bioactive assay manifested that 3,4-dichlorobenzyl compound 9e and its corresponding hydrochloride 11e showed better anti-Escherichia coli activity than Norfloxacin and Chloromycin. Preliminary research revealed that compound 9e could effectively intercalate into calf thymus DNA to form compound 9e-DNA complex which might block DNA replication and thus exert antimicrobial activities. Human serum albumin could effectively store and carry compound 9e by electrostatic interaction. (C) 2013 Published by Elsevier Ltd.