cis-[Pt(P(C6H5)2C2H5)2Cl2] | 54910-56-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis-[Pt(P(C6H5)2C2H5)2Cl2]
• 英文别名: cis-[Pt(PPh2Et)2Cl2]；cis-[PtCl2(PPh2Et)2]；[cis-(EtPh2P)2PtCl2]；cis-[PtCl2(PEtPh2)2]；ethyl(diphenyl)phosphane;platinum(2+);dichloride
• CAS: 54910-56-4；16633-76-4；39693-44-2
• 化学式: C₂₈H₃₀Cl₂P₂Pt
• 分子量: 694.48
• InChiKey: BKRRFQFJCTWKOB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  0.28
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis-[Pt(P(C6H5)2C2H5)2Cl2] 在 potassium iodide 作用下， 以 丙酮 为溶剂， 生成
  参考文献：
  名称：

  Kukushkin, Yu. N.; Sedova, G. N.; Aleshin, V. E., Russian Journal of Inorganic Chemistry, 1978, vol. 23, p. 1168 - 1170

  摘要：

  DOI：
• 作为产物：
  描述：

  tetrakis(ethyldiphenyl-l5-phosphaneyl)platinum(VI) tetrachloroplatinate(II) 以 solid 为溶剂， 生成 cis-[Pt(P(C6H5)2C2H5)2Cl2]
  参考文献：
  名称：

  Kukushkin, Yu. N.; Sedova, G. N.; Aleshin, V. E., Russian Journal of Inorganic Chemistry, 1978, vol. 23, p. 1168 - 1170

  摘要：

  DOI：

文献信息

• Reactions of organotin(IV) compounds with platinum complexes. Part(III). Reactions of (R2Sn)n, (R=Me or Ph, n=6; R=Et, n=9) with platinum complexes
  作者：Talal A.K Al-Allaf

  DOI：10.1016/s0022-328x(02)01331-1

  日期：2002.7

  oxidative-addition of the formed tin(IV) species to give complexes containing PtSn bonds. With (Ph2Sn)6 and [PtPh2L2], the mechanism takes a different course. Reactions under similar conditions involving the Pt(0) complexes [Pt(C2H4)(PPh3)2] or [Pt(COD)2], (COD=1,5-cyclooctadiene) and (R2Sn)6, R=Me or Ph, gave no detectable complexes containing PtSn bonds. The complex [Pt(PEt3)4] and (MeSn)6 likewise gives no species

  当环状化合物（R 2 Sn）n，R ＝ Me或Ph，n＝ 6时，形成R 2 Sn部分。R =的Et，Ñ = 9，暴露于光，与铂反应（II）配合物[氯铂酸2大号2 ]，L = PET 3，PPR 3，PBU 3，PEtPh 2，PPH 3，得到的新的复合物通式[PTCl（SnR 2 Cl）L 2 ]。类似地，等2的Sn从（ET 2 Sn）的9分与[PTME（CL）L-发生反应2 ]，得到[PTME（SNET 2氯）L- 2]且Ph 2从（PH的Sn 2 Sn）的6分与[乍得人道主义保护（CL）L-发生反应2 ]或[乍得人道主义保护2大号2 ]，得到[乍得人道主义保护（SnPh 2氯）L- 2 ]或[乍得人道主义保护（SnPh 3）L- 2 ]（L = PEt 3）。涉及（R 2 Sn）n与桥联络合物[PT（μ-Cl）ClL} 2 ]的反应，得到[PTCl（SnR 2 Cl）L 2 ]和[PTCl（SnRCl
• Cytotoxic platinum(II) complexes derived from saccharinate and phosphine ligands: synthesis, structures, DNA cleavage, and oxidative stress-induced apoptosis
  作者：Ceyda Icsel、Veysel T. Yilmaz、Buse Cevatemre、Muhittin Aygun、Engin Ulukaya

  DOI：10.1007/s00775-019-01736-4

  日期：2020.2

  synthesized and fully characterized; their structures were determined by X-ray crystallography. All the complexes were investigated for their anticancer potentials on three human cancer cells including A549 (lung), MCF-7 (breast), and HCT116 (colon) in addition to a noncancerous human bronchial epithelial cells (BEAS-2B). Specifically, 1 and 3 showed significant cytotoxic effects against MCF-7 and HCT116 cell

  一系列与烷基苯基膦类结构相关的糖精铂（II）配合物，即顺式-[Pt（sac）2（PPh 2 Me）2 ]·DMSO（1），顺式-[Pt（sac）2（PPhMe 2）2 ]（2），顺式-[Pt（sac）2（PPh 2 Et）2 ]（3）和顺式-[Pt（sac）2（PPhEt 2）2 ]·2DMSO（4），经过综合和充分表征；通过X射线晶体学确定它们的结构。除了非人类支气管上皮细胞（BEAS-2B）以外，还研究了所有复合物对三种人类癌细胞（包括A549（肺），MCF-7（乳腺癌）和HCT116（结肠））的抗癌潜力。具体而言，与顺铂相比，1和3对MCF-7和HCT116细胞系显示出显着的细胞毒性作用，被认为是该系列中最有效的细胞毒作用。发现细胞毒性复合物有效切割DNA。另外，通过酶抑制和分子对接研究证实了复合物与DNA的结合相互作用。配合物1和3能够诱导细胞凋亡并将细胞周期停滞在MCF-7细胞的
• Kukushkin, Yu. N.; Sedova, G. N.; Antonov, P. G., Russian Journal of Inorganic Chemistry, 1977, vol. 22, p. 1512 - 1514
  作者：Kukushkin, Yu. N.、Sedova, G. N.、Antonov, P. G.、Mitronina, L. N.

  DOI：——

  日期：——
• Reactions of R2P–P(SiMe3)2 with . Syntheses and structures of [μ2-(1,2:2-η-P2){Pt(PEt3)2}2{Pt(PEt3)2Cl}]+Cl−, [{(Et2PhP)2Pt}2P2], [{(p-Tol3P)2Pt}2P2] and [(p-Tol3P)ClPt(μ-PPh2)2Pt(p-Tol3P)Cl]
  作者：Wioleta Domańska-Babul、Jaroslaw Chojnacki、Eberhard Matern、Jerzy Pikies

  DOI：10.1016/j.jorganchem.2007.04.045

  日期：2007.8

  The reactions of diphosphanes R2P-P(SiMe3)(2) (R = Ph, 'Bu, Et2N and 'Pr2N) with [(R-3'P)(2)PtCl2] (R-3'P=Me3P, Et3P, Et2PhP, EtPh2P 3 and p-Tol(3)P) are very complex. The main reaction pathway is splitting of the P-P bond of the parent R2P-P(SiMe3)2 followed by P-31 NMR spectroscopy. The molecular formation of [(R'P-3)(2)Pt}(2)P-2], R2P-PR2 and other products which have been characterized by 3 structures of [(Et2PhP)(2)Pt}(2)P-2], [(p-Tol(3)P)(2)Pt}(2)P-2].2Et(2)O, [mu(2)-(1,2:2-eta-P-2)Pt(PEt3)(2)}(2)Pt(PEt3)(2)Cl}]Cl-+(-) and [(p-Tol(3)P)ClPt(mu-PPh2)(2)Pt(p-Tol(3)P)Cl] have been determined by single-crystal X-ray structural analysis. (c) 2007 Elsevier B. V. All rights reserved.