bilianic acid | 474-23-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: bilianic acid
• 英文别名: Biliansaeure；7.12-Dioxo-3.4-seco-5β-cholantrisaeure-(3.4.24)；Oxododecahydro-1H-cyclopenta[a]naphthalene-7-carboxylic acid；(3R,3aR,5aS,6R,7S,9aR,9bS)-3-[(2R)-4-carboxybutan-2-yl]-6-(2-carboxyethyl)-3a,6-dimethyl-4,9-dioxo-2,3,5,5a,7,8,9a,9b-octahydro-1H-cyclopenta[a]naphthalene-7-carboxylic acid
• CAS: 474-23-7
• 化学式: C₂₄H₃₄O₈
• 分子量: 450.529
• InChiKey: WXUSZELTMZPETG-MHFDELKKSA-N

物化性质

• 熔点：
  276 °C
• 沸点：
  689.8±55.0 °C(Predicted)
• 密度：
  1.253±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  bilianic acid 在 氯仿 、 五氯化磷 作用下， 生成 7,7-dichloro-12-oxo-3,4-seco-5β-cholanetrioic acid-(3.4.24)
  参考文献：
  名称：

  Geometrical entropies. The extended entropy

  摘要：

  By taking into account a geometrical interpretation of the measurement process [1,2], we define a set of measures of uncertainty. These measures will be called geometrical entropies. The amount of information is defined by considering the metric structure in the probability space. Shannon-von Neumann entropy is a particular element of this set. We show the incompatibility between this element and the concept of variance as a measure of the statistical fluctuations. When the probability space is endowed with the generalized statistical distance proposed in reference [3], we obtain the extended entropy. This element, which belongs to the set of geometrical entropies: is fully compatible with the concept of variance. Shannon-von Neumann entropy is recovered as an approximation of the extended entropy. The behavior of both entropies is compared in the case of a particle in a square-well potential.

  DOI：

  10.1007/s100510070125
• 作为产物：
  描述：

  4ξ-bromo-3,7,12-trioxo-5β(?)-cholan-24-oic acid 在 sodium hydroxide 、 potassium permanganate 作用下， 生成 bilianic acid
  参考文献：
  名称：

  Borsche; Diacont, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1931, vol. 198, p. 115,124

  摘要：

  DOI：

文献信息

• The unusual profile of the radio pulsar Geminga
  作者：V. M. Malofeev、O. I. Malov

  DOI：10.1134/1.163823

  日期：2000.1

  The results of observations of the radio emission profiles of the Geminga pulsar at 102.5, 87, 58, and 39 MHz are reported. Individual pulses are presented for the first time, and rare occasions of strong emission over the entire pulsar rotation period have been detected. A detailed analysis of the shapes, durations, and arrival phases of the pulses at 102.5 MHz is presented. These data reflect the unique character of the radio emission of Geminga.

  报告了杰敏加脉冲星在102.5、87、58和39 MHz频率下的射电发射轮廓观测结果。首次展示了单个脉冲，并且在脉冲星整个旋转周期内检测到了强发射的罕见情况。对102.5 MHz下脉冲的形状、持续时间和到达相位进行了详细分析。这些数据反映了杰敏加射电发射的独特特征。
• Absence of Drug Interaction between Oral Moxifloxacin and Intramuscular Morphine Sulfate in Healthy Volunteers
  作者：Alan S. Hollister、Vipin Agarwal、Brad Dain、John Lettieri

  DOI：10.2165/00044011-200121010-00011

  日期：——

  To determine the effects of intramuscular morphine sulfate on the pharmacokinetics of moxifloxacin. This was a single-centre, randomised, two-way, nonblinded crossover study in healthy young males and females. 20 healthy volunteers (15 males, five females) with a mean age of 34 years were enrolled and considered evaluable for the pharmacokinetic analysis. Moxifloxacin was given under two conditions separated by a minimum 7-day washout period: alone as a single oral 400mg dose, and immediately following 10mg of intramuscular morphine sulfate. Concentrations of moxifloxacin in serum were determined by a validated HPLC procedure with fluorescence detection. Pharmacokinetic parameters estimated were maximum serum concentration (Cmax), time to reach Cmax (tmax), area under the concentration-time curve from zero to infinity (AUC∞), and terminal elimination half-life (t1/2). The natural logarithms of AUC∞ and Cmax were compared by analysis of variance. The mean moxifloxacin serum concentration vs time profiles were similar between the two treatments. The geometric least square mean Cmax values for moxifloxacin were 3.42 mg/L when given alone vs 2.85 mg/L with morphine, producing a ratio (moxifloxacin with morphine vs moxifloxacin alone) of 0.83, with a 90% confidence interval (CI) about the ratio of 0.71 to 0.98. The geometric mean AUC∞ values for moxifloxacin alone and with morphine were 41.5 and 39.6 mg/L·h; the ratio of means was 0.96, with a 90% CI of 0.87 to 1.04. tmax and t1/2 values for moxifloxacin were unchanged when coadministered with morphine. The single oral dose of moxifloxacin 400mg was well tolerated when taken with and without morphine sulfate. Administration of a single intramuscular dose of morphine did not reduce the bioavailability or alter the elimination profile of oral moxifloxacin. These results suggest that concurrent administration of intramuscular morphine and oral moxifloxacin is unlikely to reduce the efficacy of the quinolone.

  注剂量的硫酸吗啡后，服用莫西沙星400mg，耐受性良好。
• Borsche; Hallwass, Chemische Berichte, 1922, vol. 55, p. 3318,3323
  作者：Borsche、Hallwass

  DOI：——

  日期：——
• Mylius, Chemische Berichte, 1887, vol. 20, p. 1968,1981
  作者：Mylius

  DOI：——

  日期：——
• Noguchi, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1932, vol. 209, p. 249,251
  作者：Noguchi

  DOI：——

  日期：——