dihydrothebainone-4-phenyl ether ethylene glycol ketal | 74924-36-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: dihydrothebainone-4-phenyl ether ethylene glycol ketal
• CAS: 74924-36-0
• 化学式: C₂₆H₃₁NO₄
• 分子量: 421.536
• InChiKey: XRWPILOAFHNHOU-BKSPAHHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.53
• 重原子数：
  31.0
• 可旋转键数：
  3.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  40.16
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  dihydrothebainone-4-phenyl ether ethylene glycol ketal 在 氨 、 sodium 作用下， 以 甲苯 为溶剂， 以86%的产率得到desoxydihydrothebainone ethylene glycol ketal
  参考文献：
  名称：

  Synthesis and Pharmacological Evaluation of 6,7-Indolo/Thiazolo-MorphinansFurther SAR of Levorphanol

  摘要：

  To further extend the structure-activity relationships of levorphanol, two series of novel morphinans were prepared by incorporation of an indole or aminothiazole fragment to the hexyl ring (ring C) in levorphanol. Such morphinans differed from previously reported ligands in that such indole- or aminothiazole-containing morphinans displayed enhanced binding affinity to the delta opioid receptor, while the affinity to kappa and mu receptors was slightly reduced.

  DOI：

  10.1021/jm0701674
• 作为产物：
  描述：

  二氢可待因酮 在 吡啶 、 盐酸 、 铜 、 caesium carbonate 、 对甲苯磺酸 、 溶剂黄146 、 锌 作用下， 以 苯 为溶剂， 反应 11.0h， 生成 dihydrothebainone-4-phenyl ether ethylene glycol ketal
  参考文献：
  名称：

  Synthesis and Pharmacological Evaluation of 6,7-Indolo/Thiazolo-MorphinansFurther SAR of Levorphanol

  摘要：

  To further extend the structure-activity relationships of levorphanol, two series of novel morphinans were prepared by incorporation of an indole or aminothiazole fragment to the hexyl ring (ring C) in levorphanol. Such morphinans differed from previously reported ligands in that such indole- or aminothiazole-containing morphinans displayed enhanced binding affinity to the delta opioid receptor, while the affinity to kappa and mu receptors was slightly reduced.

  DOI：

  10.1021/jm0701674