1-((4-methoxyphenyl)sulfonyl)-7-phenylindoline | 1254363-77-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-((4-methoxyphenyl)sulfonyl)-7-phenylindoline
• 英文别名: 1-(4-methoxybenzenesulfonyl)-7-phenyl-2,3-dihydro-1H-indole；1-(4-Methoxyphenyl)sulfonyl-7-phenyl-2,3-dihydroindole
• CAS: 1254363-77-3
• 化学式: C₂₁H₁₉NO₃S
• 分子量: 365.453
• InChiKey: BXKYSVHTPSOYSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-phenyl-1H-indole 在 吡啶 、 sodium cyanoborohydride 作用下， 以 溶剂黄146 为溶剂， 反应 18.0h， 生成 1-((4-methoxyphenyl)sulfonyl)-7-phenylindoline
  参考文献：
  名称：

  Pyridazine N-Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles

  摘要：

  Pyridazine N-oxides are used for the first time as precursors of metallocarbenes. These nitrogen-rich heterocycles led to the discovery of a novel acceptor and donor-acceptor enalcarbenoids. The synthetic utility of these metallocarbenes was demonstrated in the rhodium-catalyzed denitrogenative transannulation of pyridazine N-oxides with pyrroles to the valuable alkyl, 7-aryl, and 7-styryl indoles. The transannulation strategy was applied to the synthesis of a potent anticancer agent.

  DOI：

  10.1021/acs.orglett.5b03064

文献信息

• ARYL SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS
  申请人：Liou Jing-Ping

  公开号：US20110039880A1

  公开（公告）日：2011-02-17

  Aryl substituted sulfonamide compounds of formula (I): wherein bond, X, Y, R 1 , R 2 , R 3 , m, and n are defined herein. Also disclosed is a method for treating cancer with these compounds.

  公式（I）中的芳基取代磺酰胺化合物：其中键合，X，Y，R1，R2，R3，m和n在此定义。还公开了使用这些化合物治疗癌症的方法。
• US8119683B2
  申请人：——

  公开号：US8119683B2

  公开（公告）日：2012-02-21
• [EN] ARYL SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS<br/>[FR] COMPOSÉS DE SULFONAMIDE SUBSTITUÉS PAR UN ARYLE ET LEUR UTILISATION EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：UNIV TAIPEI MEDICAL

  公开号：WO2011019634A2

  公开（公告）日：2011-02-17

  Aryl substituted sulfonamide compounds of formula (I) are disclosed. Also disclosed is a method for treating cancer with these compounds.
• Pyridazine <i>N</i>-Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles
  作者：Vinaykumar Kanchupalli、Desna Joseph、Sreenivas Katukojvala

  DOI：10.1021/acs.orglett.5b03064

  日期：2015.12.4

  Pyridazine N-oxides are used for the first time as precursors of metallocarbenes. These nitrogen-rich heterocycles led to the discovery of a novel acceptor and donor-acceptor enalcarbenoids. The synthetic utility of these metallocarbenes was demonstrated in the rhodium-catalyzed denitrogenative transannulation of pyridazine N-oxides with pyrroles to the valuable alkyl, 7-aryl, and 7-styryl indoles. The transannulation strategy was applied to the synthesis of a potent anticancer agent.