(3-ethoxybut-1-ene-1,1-diyl)dibenzene | 1580495-50-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-ethoxybut-1-ene-1,1-diyl)dibenzene
• 英文别名: (3-Ethoxy-1-phenylbut-1-enyl)benzene
• CAS: 1580495-50-6
• 化学式: C₁₈H₂₀O
• 分子量: 252.356
• InChiKey: SPEYRKIXORHVLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙醚 、 phenyl 3-phenylpropiolate 在 二叔丁基过氧化物 、 copper(I) bromide 作用下， 反应 16.0h， 以80%的产率得到(3-ethoxybut-1-ene-1,1-diyl)dibenzene
  参考文献：
  名称：

  Oxidative difunctionalization of alkynoates via cascade radical addition, aryl migration, and decarboxylation

  摘要：

  A cascade radical oxidative difunctionalization of alkynoates with simple ethers for the construction of tri-substituted olefins is developed. The reaction undergoes cascade radical addition to C-C triple bond, 1,4-aryl migration, and decarboxylation to deliver a variety of difunctionalized alkenes in moderate to good yields. This procedure also represents a promising strategy for the direct functionalization of the alpha-Csp(3)-H bonds in ether derivatives. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.092

文献信息

• Rhenium-catalyzed dehydrogenative olefination of C(sp³)–H bonds with hypervalent iodine(<scp>iii</scp>) reagents
  作者：Haidong Gu、Congyang Wang

  DOI：10.1039/c5ob00619h

  日期：——

  dehydrogenative olefination of C(sp3)–H bonds is disclosed here, by merging rhenium catalysis with an alanine-derived hypervalent iodine(III) reagent. Thus, cyclic and acyclic ethers, toluene derivatives, cycloalkanes, and nitriles are all successfully alkenylated in a regio- and stereoselective manner.

  通过合并rh催化与丙氨酸衍生的高价碘（III）试剂，本文公开了C（sp 3）-H键的脱氢烯化反应。因此，环状和非环状醚，甲苯衍生物，环烷烃和腈都以区域和立体选择性的方式成功地被烯基化。
• Copper-catalysed oxidative C–H/C–H coupling between olefins and simple ethers
  作者：Dong Liu、Chao Liu、Heng Li、Aiwen Lei

  DOI：10.1039/c4cc00867g

  日期：——

  The first copper-catalysed oxidative alkenylation of simple ethers to construct allylic ethers was successfully achieved. Different substituted olefins and simple ethers could be cross-coupled well to generate the corresponding alkenylation products. Notably, open-chain ethers were also found to be efficient coupling partners in this reaction. This reaction is likely to proceed via a radical process

  成功实现了首次铜催化的简单醚的氧化烯基化反应，以构建烯丙基醚。不同的取代烯烃和简单的醚可以很好地交联生成相应的烯基化产物。值得注意的是，还发现开链醚是该反应中的有效偶联伙伴。该反应很可能通过自由基过程进行。