2-((2-amino-6-(benzyloxy)-9H-purin-9-yl)methoxy)ethyl acetate | 1292801-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-((2-amino-6-(benzyloxy)-9H-purin-9-yl)methoxy)ethyl acetate
• CAS: 1292801-99-0
• 化学式: C₁₇H₁₉N₅O₄
• 分子量: 357.369
• InChiKey: AYHLBXUEKDJCOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.52
• 重原子数：
  26.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  114.38
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  2-((2-amino-6-(benzyloxy)-9H-purin-9-yl)methoxy)ethyl acetate 在 甲醇 、 sodium methylate 作用下， 以74%的产率得到2-((2-amino-6-(benzyloxy)-9H-purin-9-yl)methoxy)ethanol
  参考文献：
  名称：

  Real-Time Measurements of Protein Dynamics Using Fluorescence Activation-Coupled Protein Labeling Method

  摘要：

  We present a fluorescence activation-coupled protein labeling (FAPL) method, which employs small-molecular probes that exhibit almost no basal fluorescence but acquire strong fluorescence upon covalent binding to tag-proteins. This method enables real-time imaging of protein labeling without any washout process and is uniquely suitable for real-time imaging of protein dynamics on the cell surface. We applied this method to address the spatiotemporal dynamics of the EGF receptor during cell migration.

  DOI：

  10.1021/ja200225m
• 作为产物：
  描述：

  阿昔洛韦 在 吡啶 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 生成 2-((2-amino-6-(benzyloxy)-9H-purin-9-yl)methoxy)ethyl acetate
  参考文献：
  名称：

  Real-Time Measurements of Protein Dynamics Using Fluorescence Activation-Coupled Protein Labeling Method

  摘要：

  We present a fluorescence activation-coupled protein labeling (FAPL) method, which employs small-molecular probes that exhibit almost no basal fluorescence but acquire strong fluorescence upon covalent binding to tag-proteins. This method enables real-time imaging of protein labeling without any washout process and is uniquely suitable for real-time imaging of protein dynamics on the cell surface. We applied this method to address the spatiotemporal dynamics of the EGF receptor during cell migration.

  DOI：

  10.1021/ja200225m